Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials
Kazuo Azuma,Ryotaro Izumi,Tomohiro Osaki,Shinsuke Ifuku,Minoru Morimoto,Hiroyuki Saimoto,Saburo Minami,Yoshiharu Okamoto +7 more
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TLDR
The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process and also indicate that some nano-based materials from chitIn and chitOSan are beneficial than chit in and chITosan for wound healing.Abstract:
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.read more
Citations
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Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications.
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TL;DR: The most common chitosan processing methods are summarized and some applications of chitOSan in various industrial and biomedical fields are highlighted, including antibacterial activity, non-toxicity, ease of modification, and biodegradability.
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Hydrogel wound dressings for bioactive treatment of acute and chronic wounds
TL;DR: A variety of approaches to bioactive wound healing, such as bioactive dressing materials, use of antimicrobial agents, inclusion of biological signaling molecules like growth factors, and incorporation of seeded stem cells, are considered and critically evaluated.
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