Chronic Opioid Treatment Induces Adenylyl Cyclase V Superactivation INVOLVEMENT OF Gβγ
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TLDR
It is shown that this phenomenon can be reproduced and studied in COS-7 cells cotransfected with adenylyl cyclase type V and μ-opioid receptor cDNAs, and that it is not affected by the Ras dominant negative mutant N17-Ras.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-08-30 and is currently open access. It has received 196 citations till now. The article focuses on the topics: ADCY10 & Adenylyl cyclase.read more
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Cellular and synaptic adaptations mediating opioid dependence.
TL;DR: A review on the adaptive changes in cellular and synaptic function induced by chronic morphine treatment can be found in this article, where the initial steps of opioid action are mediated through the activation of G protein-linked receptors.
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Regulation and Role of Adenylyl Cyclase Isoforms
Jacques Hanoune,Nicole Defer +1 more
TL;DR: The present review deals with various aspects of regulations, emphasizing the role of calcium/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect of calcium on AC5 and AC6, and the changes in the expression pattern of the isoforms during development.
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Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.
Roger K. Sunahara,Ronald Taussig +1 more
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Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.
TL;DR: The present review focuses on the potential physiological regulations involving different isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of cAMP from ATP, emphasizing the role of Ca(2+)/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect ofCa(2+) on AC5 and AC6, and the changes in the expression pattern of the isoforms during development.
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Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.
TL;DR: It is demonstrated that [D-Ala(2)-MePhe(4)-Gly(5)-ol] enkephalin (DAMGO) can facilitate the ability of morphine to stimulate MOR endocytosis, and hence suggest an approach for the development of opiate analogs with enhanced efficacy for the treatment of chronic pain.
References
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G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Drugs of abuse: anatomy, pharmacology and function of reward pathways
TL;DR: The results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.
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Identification of a family of muscarinic acetylcholine receptor genes
TL;DR: Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence.
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Cloning of a delta opioid receptor by functional expression
TL;DR: A complementary DNA clone encoding a functional delta opioid receptor has been identified and shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8.
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Receptor-effector coupling by G proteins
TL;DR: To facilitate the reading of this review, the various subtopics of this rapidly expanding field are presented, each of which is organized as a self-contained sub-chapter that can be read independently of the others.