Clathrin-Independent Pathways of Endocytosis
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TLDR
This review explores pathways of endocytosis that occur in the absence of clathrin that are likely to play key roles in the regulation of plasma membrane area and tension and also control the availability of membrane during cell migration.Abstract:
There are many pathways of endocytosis at the cell surface that apparently operate at the same time. With the advent of new molecular genetic and imaging tools, an understanding of the different ways by which a cell may endocytose cargo is increasing by leaps and bounds. In this review we explore pathways of endocytosis that occur in the absence of clathrin. These are referred to as clathrin-independent endocytosis (CIE). Here we primarily focus on those pathways that function at the small scale in which some have distinct coats (caveolae) and others function in the absence of specific coated intermediates. We follow the trafficking itineraries of the material endocytosed by these pathways and finally discuss the functional roles that these pathways play in cell and tissue physiology. It is likely that these pathways will play key roles in the regulation of plasma membrane area and tension and also control the availability of membrane during cell migration.read more
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References
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Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
Journal ArticleDOI
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Marek Drab,Paul Verkade,Marlies Elger,Michael Kasper,Matthias Lohn,Matthias Lohn,Birgit Lauterbach,Birgit Lauterbach,Jan Menne,Carsten Lindschau,Carsten Lindschau,Fanny Mende,Friedrich C. Luft,Andreas Schedl,Hermann Haller,Teymuras V. Kurzchalia +15 more
TL;DR: By targeted disruption of caveolin-1, the main protein component of caveolae, mice that lacked Caveolae were generated, causing aberrations in endothelium-dependent relaxation, contractility, and maintenance of myogenic tone and indicating a fundamental role in organizing multiple signaling pathways in the cell.
Journal ArticleDOI
Pathways of clathrin-independent endocytosis.
Satyajit Mayor,Richard E. Pagano +1 more
TL;DR: The current understanding of various clathrin-independent mechanisms of endocytosis are reviewed and a classification scheme is proposed to help organize the data in this complex and evolving field.
Journal ArticleDOI
Pathways and mechanisms of endocytic recycling.
TL;DR: This work emphasizes the importance of regulated recycling in processes as diverse as cytokinesis, cell adhesion, morphogenesis, cell fusion, learning and memory.