Journal ArticleDOI
Clinical features of hepatocellular carcinoma with extrahepatic metastases
Mitsuteru Natsuizaka,Takumi Omura,Toru Akaike,Yasuaki Kuwata,Katsu Yamazaki,Takahiro Sato,Yoshiyasu Karino,Jouji Toyota,Toshihiro Suga,Masahiro Asaka +9 more
Reads0
Chats0
TLDR
The purpose of the present study was to elucidate the clinical features of extrahepatic metastases of HCC.Abstract:
Background: There are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (HCC). The purpose of the present study was to elucidate the clinical features of extrahepatic metastases of HCC.
Methods: The clinical records of 482 patients who had been diagnosed as having HCC during the period from January 1995 to March 2001 were retrospectively reviewed. Extrahepatic metastases had been detected in 65 patients. Clinical features of those 65 patients were analyzed.
Results: Patients with extrahepatic metastases had more advanced intrahepatic tumors at the first diagnosis of HCC: 73.8% of the patients with extrahepatic metastases had tumors of intrahepatic tumor stage T3 or T4 according to the TNM classification, while only 28.5% of the patients without extrahepatic metastases had tumors of T3 or T4 (P < 0.001). Vessel invasion was also detected at the first diagnosis of HCC more frequently in the patients with extrahepatic metastasis (P < 0.001). The frequent metastatic sites were lung (53.8%), bone (38.5%), and lymph node (33.8%). Other metastatic sites were the adrenal gland, peritoneum, skin, brain and muscle. The median survival time and 1-year survival rate were 7 months (range: 1–59 months) and 24.9%, respectively. Patients with Child–Pugh grade B and C (P = 0.0018) and patients with positive serum α-fetoprotein (P = 0.011) had significantly poor prognosis.
Conclusions: Extrahepatic metastases of HCC are not rare. The possibility of extrahepatic metastases and the clinical features of extrahepatic metastases should be considered when examining patients with HCC, particularly those with advanced intrahepatic tumors, to enable precise evaluation of the spread of HCC and determination of the appropriate treatment method.
© 2005 Blackwell Publishing Asia Pty Ltdread more
Citations
More filters
Journal ArticleDOI
NCCN clinical practice guidelines in oncology: hepatobiliary cancers.
Al B. Benson,Thomas A. Abrams,Edgar Ben-Josef,P. Mark Bloomston,Jean F. Botha,Bryan M. Clary,Anne M. Covey,Steven A. Curley,Michael I. D'Angelica,Rene Davila,William D. Ensminger,John F. Gibbs,Daniel Laheru,Mokenge P. Malafa,Jorge Marrero,Steven G. Meranze,Sean J. Mulvihill,James O. Park,James A. Posey,Jasgit Sachdev,Riad Salem,Elin R. Sigurdson,Constantinos T. Sofocleous,Jean-Nicolas Vauthey,Alan P. Venook,Laura W. Goff,Yun Yen,Andrew X. Zhu +27 more
Journal ArticleDOI
Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma.
Kiminori Uka,Hiroshi Aikata,Shintaro Takaki,Hiroo Shirakawa,Soo Cheol Jeong,Keitaro Yamashina,Akira Hiramatsu,Hideaki Kodama,Shoichi Takahashi,Kazuaki Chayama +9 more
TL;DR: Treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepastic tumor stage (T0-T2), and are free of portal venous invasion may improve survival.
Journal ArticleDOI
Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors.
Koji Uchino,Ryosuke Tateishi,Shuichiro Shiina,Miho Kanda,Ryota Masuzaki,Yuji Kondo,Tadashi Goto,Masao Omata,Haruhiko Yoshida,Kazuhiko Koike +9 more
TL;DR: The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with hepatocellular carcinoma who have extrahepatic metastasis.
Journal ArticleDOI
Hepatobiliary cancers, Version 2.2021
Al B. Benson,Michael I. D’Angelica,Daniel E. Abbott,Daniel A. Anaya,Robert A. Anders,Chandrakanth Are,Melinda Bachini,Mitesh J. Borad,Daniel B. Brown,Adam M. Burgoyne,Prabhleen Chahal,Daniel T. Chang,Jordan M. Cloyd,Anne M. Covey,Evan S. Glazer,Lipika Goyal,William G. Hawkins,Renuka Iyer,Rojymon Jacob,R. Kate Kelley,Robin D. Kim,Matthew H. Levine,Manisha Palta,James O. Park,Steven S. Raman,Sanjay S. Reddy,Vaibhav Sahai,Tracey E. Schefter,Gagandeep Singh,Stacey Stein,Jean Nicolas Vauthey,Alan P. Venook,Adam C. Yopp,Nicole R. McMillian,Cindy Hochstetler,Susan Darlow +35 more
TL;DR: The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts as discussed by the authors.
Journal ArticleDOI
Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma
TL;DR: It is confirmed that 18F-FDG PET/CT is useful in the evaluation of HCC metastasis, although its role in the diagnosis of primary HCC is more limited.
References
More filters
Journal ArticleDOI
Extrahepatic Metastases of Hepatocellular Carcinoma
Sanjeev Katyal,James H. Oliver,Mark S. Peterson,James V. Ferris,Brian S. Carr,Richard L. Baron +5 more
TL;DR: The lung, abdominal lymph nodes, and bone are the most common sites of extrahepatic metastatic HCC, with patients with advanced intrahepastic tumor stage (stage IVA) most likely to have metastases.
Journal ArticleDOI
Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years.
Toshiro Nakashima,Kunio Okuda,Masamichi Kojiro,Atsuro Jimi,Ryusuke Yamaguchi,Kazuyoshi Sakamoto,Tamio Ikari +6 more
TL;DR: HCC in Japan is distinct from that in the West that it is frequently encapsulated, livers are generally small because of frequent and advanced cirrhosis and small cancer, minute HCC, is not uncommon at autopsy.
Journal ArticleDOI
Growth and spread of hepatocellular carcinoma: A review of 240 consecutive autopsy cases
TL;DR: It appears that not only primary tumor size but also its macroscopic type has an important influence on the growth and spread of HCC.
Journal ArticleDOI
Hypervascular hepatocellular carcinoma: evaluation of hemodynamics with dynamic CT during hepatic arteriography.
Kazuhiko Ueda,O Matsui,Y Kawamori,Yasuni Nakanuma,Masumi Kadoya,J Yoshikawa,T Gabata,Akitaka Nonomura,Tsutomu Takashima +8 more
TL;DR: The main drainage of hepatocellular carcinoma lesions may be a protal venule, as assessed by single-level dynamic computed tomography during hepatic arteriography.
Journal ArticleDOI
Increased incidence of bone metastases in hepatocellular carcinoma.
Marie Fukutomi,Masaki Yokota,Hirokazu Chuman,Hiroshi Harada,Yasuhisa Zaitsu,Akihiro Funakoshi,Hideyuki Wakasugi,Haruo Iguchi +7 more
TL;DR: The increased incidence of bone metastasis in hepatocellular carcinoma in the decade 1988–1997 is first attributed to the prolonged survival rate of patients due to recent progress in both the diagnosis and treatment of the disease.
Related Papers (5)
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more