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Journal ArticleDOI

Clinical practice guidelines for chronic cardiovascular disorders: a roadmap for the future.

Elliott M. Antman, +1 more
- 26 Mar 2014 - 
- Vol. 311, Iss: 12, pp 1195-1196
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TLDR
Clinicians want to provide their patients with the best possible advice with respect to the management of cardiovascular risk, often implementing evidence-based clinical practice guidelines designed to improve health outcomes.
Abstract
The World Health Organization lists ischemic heart disease and stroke as the top 2 leading causes of death worldwide in 2011, responsible for 7 million and 6.2 million deaths, respectively.1 The concept of risk factors for atherosclerotic cardiovascular disease (CVD) was introduced in 1961, based on epidemiologic observations from the Framingham Heart Study. Hypertension and abnormal blood lipid levels were key risk factors shown to be associated with an increased risk of angina pectoris, myocardial infarction, and sudden cardiac death; later, stroke was identified as an important outcome as well, especially in women and racial/ethnic subgroups. Accordingly, clinicians want to provide their patients with the best possible advice with respect to the management of cardiovascular risk, often implementing evidence-based clinical practice guidelines designed to improve health outcomes.

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Citations
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[The problem of safety of lipid-lowering therapy].

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Book ChapterDOI

Dietary Sugar Intake and Risk of Noncommunicable Diseases

TL;DR: There is a need to educate the population about the health hazards associated with sugar consumption and the sugar-sweetened beverages are a marker of an unhealthy lifestyle and their drinkers consume more calories, exercise less, smoke more, and have a poor dietary pattern.
References
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TL;DR: Further reductions in LDL cholesterol safely produce definite further reductions in the incidence of heart attack, of revascularisation, and of ischaemic stroke, with each 1·0 mmol/L reduction reducing the annual rate of these major vascular events by just over a fifth.
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Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

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Journal ArticleDOI

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials

TL;DR: Most risks and benefits dissipated postintervention, although some elevation in breast cancer risk persisted during cumulative follow-up and the 2 WHI hormone therapy trials do not support use of this therapy.
Journal ArticleDOI

Transforming Clinical Trials in Cardiovascular Disease: Mission Critical for Health and Economic Well-being

TL;DR: The National Center for Advancing Translational Sciences (NCATS) is dedicated to catalyzing innovative methods and technologies to enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of merchandiseases and conditions.
Journal ArticleDOI

Efficacy and safety of more intensive lowering of LDL cholesterol

TL;DR: The hypothesis that pravastatin therapy was associated with an increasing risk of cancer as age increased was generated and test this hypothesis with the available individual data from the CCT Collaboration would be extremely valuable.
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