Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF)
Ferenc Follath,Mehmet Yilmaz,Mehmet Yilmaz,Juan F. Delgado,John Parissis,Raphaël Porcher,Etienne Gayat,Nigel Burrows,Anthony S. McLean,Fábio Vilas-Boas,Alexandre Mebazaa +10 more
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The authors' data demonstrated the existence of different subgroups based on de novo or pre-existing episode(s) of AHF and the site of hospitalization and recognition of these subgroups might improve management and outcome by defining specific therapeutic requirements.Abstract:
We performed a survey on acute heart failure (AHF) in nine countries in four continents. We aimed to describe characteristics and management of AHF among various countries, to compare patients with de novo AHF versus patients with a pre-existing episode of AHF, and to describe subpopulations hospitalized in intensive care unit (ICU) versus cardiac care unit (CCU) versus ward. Data from 4,953 patients with AHF were collected via questionnaire from 666 hospitals. Clinical presentation included decompensated congestive HF (38.6%), pulmonary oedema (36.7%) and cardiogenic shock (11.7%). Patients with de novo episode of AHF (36.2%) were younger, had less comorbidities and lower blood pressure despite greater left ventricular ejection fraction (LVEF) and were more often admitted to ICU. Overall, intravenous (IV) diuretics were given in 89.7%, vasodilators in 41.1%, and inotropic agents (dobutamine, dopamine, adrenaline, noradrenaline and levosimendan) in 39% of cases. Overall hospital death rate was 12%, the majority due to cardiogenic shock (43%). More patients with de novo AHF (14.2%) than patients with a pre-existing episode of AHF (10.8%) (p = 0.0007) died. There was graded mortality in ICU, CCU and ward patients with mortality in ICU patients being the highest (17.8%) (p < 0.0001). Our data demonstrated the existence of different subgroups based on de novo or pre-existing episode(s) of AHF and the site of hospitalization. Recognition of these subgroups might improve management and outcome by defining specific therapeutic requirements.read more
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The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.
Andrew P. Ambrosy,Gregg C. Fonarow,Javed Butler,Ovidiu Chioncel,Stephen J. Greene,Muthiah Vaduganathan,Savina Nodari,Carolyn S.P. Lam,Naoki Sato,Ami N. Shah,Mihai Gheorghiade +10 more
TL;DR: Global HHF registries are reviewed to describe the patient characteristics, management, outcomes and their predictors, quality improvement initiatives, regional differences, and limitations of the available data and propose a roadmap for the design and conduct of future H HF registries.
Journal ArticleDOI
Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long‐Term Registry
Ovidiu Chioncel,Alexandre Mebazaa,Veli-Pekka Harjola,Andrew J.S. Coats,Massimo F Piepoli,María G. Crespo-Leiro,Cécile Laroche,Petar M. Seferović,Stefan D. Anker,Roberto Ferrari,Frank Ruschitzka,Silvia López-Fernández,Daniela Miani,Gerasimos Filippatos,Aldo P. Maggioni +14 more
TL;DR: To identify differences in clinical epidemiology, in‐hospital management and 1‐year outcomes among patients hospitalized for acute heart failure and enrolled in the European Society of Cardiology Heart Failure Long‐Term Registry, stratified by clinical profile at admission.
Journal ArticleDOI
Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine
Alexandre Mebazaa,M. Birhan Yilmaz,Phillip D. Levy,Piotr Ponikowski,W. Frank Peacock,Said Laribi,Arsen D. Ristić,Ekaterini Lambrinou,Josep Masip,Jillian P. Riley,Theresa McDonagh,Christian Mueller,Christopher DeFilippi,Veli-Pekka Harjola,Holger Thiele,Massimo F Piepoli,Marco Metra,Aldo P. Maggioni,John J.V. McMurray,Kenneth Dickstein,Kevin Damman,Petar M. Seferovic,Frank Ruschitzka,Adelino F. Leite-Moreira,Abdelouahab Bellou,Abdelouahab Bellou,Stefan D. Anker,Stefan D. Anker,Gerasimos Filippatos +28 more
TL;DR: In this article, the authors provide guidance to practicing physicians and nurses to manage acute heart failure in the pre-hospital and hospital setting, including criteria of hospitalization and of discharge, and gaps in knowledge and perspectives.
Journal ArticleDOI
Improving care for patients with acute heart failure: before, during and after hospitalization
Martin R. Cowie,Stefan D. Anker,John G.F. Cleland,John G.F. Cleland,G. Michael Felker,Gerasimos Filippatos,Tiny Jaarsma,Patrick Jourdain,Eve Knight,Barry M. Massie,Piotr Ponikowski,Jose Lopez-Sendon +11 more
TL;DR: Recommendations from structured discussions among an author group of AHF experts in 2013 are presented, which suggest that routine EMTs should be considered as a first line of treatment for acute heart failure.
Journal ArticleDOI
Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure
Maria Nikolaou,Maria Nikolaou,Maria Nikolaou,John Parissis,M. Birhan Yilmaz,Marie-France Seronde,Marie-France Seronde,Matti Kivikko,Matti Kivikko,Said Laribi,Said Laribi,Catherine Paugam-Burtz,Danlin Cai,Pasi Pohjanjousi,Pierre-François Laterre,Nicolas Deye,Pentti Põder,Alain Cohen-Solal,Alain Cohen-Solal,Alexandre Mebazaa,Alexandre Mebazaa +20 more
TL;DR: Abnormal LFTs were present in about a half of patients presenting with ADHF treated with inotropes and were associated with specific clinical, biological, and prognostic features, including a short-term overmortality with increased transaminases but not with biological signs of cholestasis, in ADHF patients.
References
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Journal ArticleDOI
ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM).
Kenneth Dickstein,Alain Cohen-Solal,Gerasimos Filippatos,John J.V. McMurray,Piotr Ponikowski,Philip A. Poole-Wilson,Anna Strömberg,Dirk J. van Veldhuisen,Dan Atar,Arno W. Hoes,Andre Keren,Alexandre Mebazaa,Markku S. Nieminen,Silvia G. Priori,Karl Swedberg,Alec Vahanian,John Camm,Raffaele De Caterina,Veronica Dean,Christian Funck-Brentano,Irene Hellemans,Steen Dalby Kristensen,Keith McGregor,Udo Sechtem,Sigmund Silber,Michal Tendera,Petr Widimsky,José Luis Zamorano,Angelo Auricchio,Jeroen J. Bax,Michael Böhm,Ugo Corrà,Paolo Della Bella,Perry M. Elliott,Ferenc Follath,Mihai Gheorghiade,Yonathan Hasin,Anders Hernborg,Tiny Jaarsma,Michel Komajda,Ran Kornowski,Massimo F Piepoli,Bernard Prendergast,Luigi Tavazzi,Jean Luc Vachiery,Freek W.A. Verheugt,Faiez Zannad +46 more
Journal ArticleDOI
Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
Kirkwood F. Adams,Gregg C. Fonarow,Charles L. Emerman,Thierry H. LeJemtel,Maria Rosa Costanzo,William T. Abraham,Robert Berkowitz,Marie Galvao,Darlene P. Horton +8 more
TL;DR: The ADHERE registry as mentioned in this paper is designed to study characteristics, management, and outcomes in a broad sample of patients hospitalized with acute decompensated heart failure, which is a leading cause of hospitalization for adults older than 65 years in the United States.
Journal ArticleDOI
Risk Stratification for In-Hospital Mortality in Acutely Decompensated Heart Failure: Classification and Regression Tree Analysis
TL;DR: The results suggest that ADHF patients at low, intermediate, and high risk for in-hospital mortality can be easily identified using vital sign and laboratory data obtained on hospital admission and provides clinicians with a validated, practical bedside tool for mortality risk stratification.
Journal ArticleDOI
The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis.
John G.F. Cleland,Karl Swedberg,Ferenc Follath,Michel Komajda,Alain Cohen-Solal,J.C. Aguilar,Rainer Dietz,Antonello Gavazzi,R. Hobbs,Jerzy Korewicki,Hugo Madeira,V. S. Moiseyev,István Préda,W. H. Van Gilst,J Widimsky,Nick Freemantle,Joanne Eastaugh,James Mason +17 more
TL;DR: Most men but a minority of women who underwent investigation of cardiac function had evidence of moderate or severe left ventricular dysfunction, the main target of current advances in the treatment of heart failure.
Journal ArticleDOI
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology.
Markku S. Nieminen,Silvia G. Priori,Maria Angeles Alonso Garcia,Andrzej Budaj,Enrique Fernandez Burgos,John Lekakis,Gianfranco Mazzotta,Otto A. Smiseth,Kenneth Dickstein,María G. Crespo-Leiro,Roberto Ferrari +10 more
TL;DR: It is of great importance that guidelines and recommendations are presented in formats that are easily interpreted and their implementation programmes must also be well conducted.
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