Journal ArticleDOI
Clinical significance of HuR expression in human malignancy
TLDR
Elevated HuR expression levels and mainly cytoplasmic immunohistochemical pattern were correlated with decreased patients’ survival rate in various human tumors, verifying its possible clinical significance.Abstract:
Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to summarize and present the currently available information in the English literature on HuR expression in various human tumors, verifying its possible clinical significance. HuR function is directly linked to its subcellular localization. In normal cells, HuR is mostly localized in the nucleus, while in malignant cells, an increase in cytoplasmic HuR levels has been noted, in both cell lines and tissue samples. Moreover, in malignancy, elevated HuR expression levels and cytoplasmic immunohistochemical pattern have been correlated with advanced clinicopathological parameters and altered expression levels of proteins implicated in neoplasia. Additionally, elevated HuR expression levels and mainly cytoplasmic immunohistochemical pattern were correlated with decreased patients’ survival rate in various human tumors. HuR is a putative drug target for cancer therapy, since it is expressed ubiquitously in malignant clinical samples and has an apparently consistent role in tumor formation and progression.read more
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Journal ArticleDOI
HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer.
Qing Tang,Swei Sunny Hann +1 more
TL;DR: HX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability.
Journal ArticleDOI
Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Yajun Chen,Feng Yang,Erhu Fang,Xiao Wenjing,Hong Mei,Huanhuan Li,Dan Li,Huajie Song,Jianqun Wang,Mei Hong,Xiaojing Wang,Kai Huang,Liduan Zheng,Qiangsong Tong +13 more
TL;DR: Results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Journal ArticleDOI
Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
Feng Yang,Anpei Hu,Dan Li,Jianqun Wang,Yanhua Guo,Yang Liu,Hongjun Li,Yajun Chen,Xiaojing Wang,Kai Huang,Liduan Zheng,Qiangsong Tong +11 more
TL;DR: Circ-HuR serves as a tumor suppressor to inhibit CNBP-facilitated HuR expression and gastric cancer progression, indicating a potential therapeutic target for gastric cancers.
Journal ArticleDOI
Auto-regulatory feedback by RNA-binding proteins.
TL;DR: RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range or generates binary, genetic on/off switches important for e.g. cell fate decisions (by positive feedback) is reviewed.
Journal ArticleDOI
Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma.
TL;DR: It is revealed that MIR22HG plays a key role in tumor progression by suppressing the proliferation, invasion, and metastasis of tumor cells, suggesting its potential role as a tumor suppressor and prognostic biomarker in HCC.
References
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Journal ArticleDOI
Conserved structures and diversity of functions of RNA-binding proteins.
TL;DR: The major RNA-binding motifs are described and examples of how they may function are given.
Journal ArticleDOI
HuR and mRNA stability
TL;DR: The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change.
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Overexpression of hur, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of are-containing mrnas
TL;DR: HuR may initially bind to ARE‐containing mRNAs in the nucleus and provide protection during and after their export to the cytoplasmic compartment, establishing an in vivo role for HuR in mRNA decay.
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Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR
TL;DR: Using an S-100 extract, it is shown that the addition of recombinant HuR stabilizes VEGF mRNA markedly and support the critical role of HuR in mediating the hypoxic stabilization of V EGF mRNA by hypoxia.
Journal ArticleDOI
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein.
TL;DR: A fourth member of this family of neuronal-specific Elav-like proteins that binds avidly to the AU-rich element in c-fos and interleukin-3 mRNAs is identified and cloned.