Journal ArticleDOI
Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system
TLDR
The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume.Abstract:
✓ The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume. Cerebral and spinal compartments were isolated by inflating a balloon positioned epidurally at the level of C-6. The change of CSF volume per unit change in pressure (compliance) and change of CSF volume per unit of time (absorption) were evaluated by inserting pressure data from the experimental responses into a series of equations developed from a mathematical model. It was found that 68% of total compliance is contributed by the cerebral compartment while the remaining 32% is contained within the spinal axis. The cerebral compartment accounted for 84% of total CSF absorption. The mechanism for spinal absorption appears to be similar in that no differences were obvious on the basis of pressure dynamics.read more
Citations
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Posted ContentDOI
Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation
TL;DR: In this article , the authors identify and quantify CSF tracer transport parameters using forward and inverse subject-specific computational modeling and support the notion that extracellular diffusion alone is not sufficient as a brain-wide transport mechanism, instead, they show that human MRI observations align well with transport by either substantially enhanced (3.5×) extrachromatic diffusion in combination with local clearance rates corresponding to a tracer half-life of up to 5 hours, or by extrascale diffusion augmented by advection with brainwide average flow speeds on the order of 1-9 µm/min.
Book ChapterDOI
CSF Dynamics and Cerebral Hemodynamics in ATP-Induced Hypotension
A. Schettini,E. K. Walsh +1 more
TL;DR: Induced hypotension is frequently used in neurosurgery, particularly in operations involving cerebral aneurysms and vascular tumors, and the hypotensive agent adenosine triphosphate has been shown to produce controllable decreases in systemic arterial pressure.
Journal ArticleDOI
Intercompartmental communication between the cerebrospinal and adjacent spaces during intrathecal infusions in an acute ovine in-vivo model
Anthony Podgoršak,Nina Eva Trimmel,Markus Florian Oertel,Sara Qvarlander,Margarete Arras,Anders Eklund,Miriam Weisskopf,Marianne Schmid Daners +7 more
TL;DR: In this article , an in-vivo sheep trial was conducted to evaluate and quantify the communication existing within the cranio-spinal, arterial, and venous systems (1 kHz sampling frequency).
Book ChapterDOI
Study of the CSF Pulsation Transfer: Application to the Frequency Analysis
TL;DR: In this article, the physical properties of the cranio-spinal cavity and its contents have been investigated by the volume/pressure test, and the properties have been proved to be stable.
References
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Journal ArticleDOI
A simple constant‐infusion manometric test for measurement of CSF absorption: I. Rationale and method
Robert Katzman,Francis Hussey +1 more
Journal ArticleDOI
The pressure-volume curve of the cerebrospinal fluid space in dogs
TL;DR: The cerebrospinal fluid pressure‐volume curve was determined by measuring the pressure response to rapid injection of fluid into the cisterna magna of dogs, by means of a constant flow infusion pump.
Journal ArticleDOI
Cranial and spinal components of the cerebrospinal fluid pressure‐volume curve
Jan Löfgren,Nicolaus N. Zwetnow +1 more
TL;DR: A quantitative analysis of the contributions of the cranial and spinal compartments to the cerebrospinal fluid pressure‐volume curve was made using dogs using dogs to represent the effects on the fluid pressure of forced alterations in the volume of the intracranial vascular bed.
Journal ArticleDOI
The mechanism of the change in cerebrospinal fluid pressure following an induced change in the volume of the fluid space.
Henry W. Ryder,Frank F. Espey,Fariss D. Kimbell,Ernest J. Penka,Adolf Rosenauer,Boris Podolsky,Joseph P. Evans +6 more
Journal ArticleDOI
Pressure-Volume Considerations in Infantile Hydrocephalus
Kenneth Shulman,Anthony Marmarou +1 more
TL;DR: Evidence of normal ventricular pressure does not exclude the possibility of progressive hydrocephalus, and increased pressure is likely to occur for quite long periods while the hydrocephalic infant is engaged in normal infantile activities.
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A simple constant‐infusion manometric test for measurement of CSF absorption: I. Rationale and method
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