Journal ArticleDOI
Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system
TLDR
The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume.Abstract:
✓ The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume. Cerebral and spinal compartments were isolated by inflating a balloon positioned epidurally at the level of C-6. The change of CSF volume per unit change in pressure (compliance) and change of CSF volume per unit of time (absorption) were evaluated by inserting pressure data from the experimental responses into a series of equations developed from a mathematical model. It was found that 68% of total compliance is contributed by the cerebral compartment while the remaining 32% is contained within the spinal axis. The cerebral compartment accounted for 84% of total CSF absorption. The mechanism for spinal absorption appears to be similar in that no differences were obvious on the basis of pressure dynamics.read more
Citations
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Journal ArticleDOI
Ventricle Equilibrium Position in Healthy and Normal Pressure Hydrocephalus Brains Using an Analytical Model
TL;DR: An analytical model using Darcy's and Biot's equations and simplifying the brain geometry to a hollow sphere with an internal and external radius is proposed and is able to predict the onset and development of NPH conditions as a deviation from healthy conditions.
Journal ArticleDOI
Effects of exsanguination and sodium nitroprusside on compliance of the spinal canal during aortic occlusion
Robert E. Maughan,Robert E. Maughan,Chittur Mohan,Chittur Mohan,Ronald Levy,Ronald Levy,Joseph N. Cunningham,Joseph N. Cunningham,Israel J. Jacobowitz,Israel J. Jacobowitz,Corrado P. Marini,Corrado P. Marini +11 more
TL;DR: To evaluate the effects of sodium nitroprusside and partial exsanguination on systemic hemodynamics and cerebrospinal fluid dynamics, 10 mongrel dogs during aortic cross-clamping of the descending thoracic aorta and after control of proximal hypertension with EXS and SNP were monitored.
Book ChapterDOI
Regulation of the Circulation of the Brain
TL;DR: Among the physiological or pathological disturbances that the cerebrovascular bed must be able to face during human or animal life, mention can be made of alterations in arterial or intracranial pressure, body postural changes, variations in brain metabolism, and changes in blood gas content.
Book ChapterDOI
Physical phantom of craniospinal hydrodynamics.
TL;DR: The phantom shows that CSF oscillations directly result from arteriovenous flow, and intracranial pressure measurements show that the model obeys an exponential relationship between pressure and intrACranial volume expansion.
Journal ArticleDOI
A pressure controller for estimating parameters for a nonlinear CSF model
TL;DR: The steady-state pressure and infusion rate were used to estimate the parameters of CSF formation and CSF absorption using the nonlinear least-squares method and the CSF compliance was estimated using the transient portion of the pressure/infusion rate responses.
References
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Journal ArticleDOI
A simple constant‐infusion manometric test for measurement of CSF absorption: I. Rationale and method
Robert Katzman,Francis Hussey +1 more
Journal ArticleDOI
The pressure-volume curve of the cerebrospinal fluid space in dogs
TL;DR: The cerebrospinal fluid pressure‐volume curve was determined by measuring the pressure response to rapid injection of fluid into the cisterna magna of dogs, by means of a constant flow infusion pump.
Journal ArticleDOI
Cranial and spinal components of the cerebrospinal fluid pressure‐volume curve
Jan Löfgren,Nicolaus N. Zwetnow +1 more
TL;DR: A quantitative analysis of the contributions of the cranial and spinal compartments to the cerebrospinal fluid pressure‐volume curve was made using dogs using dogs to represent the effects on the fluid pressure of forced alterations in the volume of the intracranial vascular bed.
Journal ArticleDOI
The mechanism of the change in cerebrospinal fluid pressure following an induced change in the volume of the fluid space.
Henry W. Ryder,Frank F. Espey,Fariss D. Kimbell,Ernest J. Penka,Adolf Rosenauer,Boris Podolsky,Joseph P. Evans +6 more
Journal ArticleDOI
Pressure-Volume Considerations in Infantile Hydrocephalus
Kenneth Shulman,Anthony Marmarou +1 more
TL;DR: Evidence of normal ventricular pressure does not exclude the possibility of progressive hydrocephalus, and increased pressure is likely to occur for quite long periods while the hydrocephalic infant is engaged in normal infantile activities.
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