Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2
J. Pablo Abonia,K. Frank Austen,Barrett J. Rollins,Sunil K. Joshi,Richard A. Flavell,William A. Kuziel,Pandelakis A. Koni,Michael F. Gurish +7 more
TLDR
The establishment and maintenance of MCps in the small intestine is a dynamic process that requires expression of the alpha4beta7 integrin and the alpha-chemokine receptor CXCR2.About:
This article is published in Blood.The article was published on 2005-06-01 and is currently open access. It has received 113 citations till now. The article focuses on the topics: CC chemokine receptors & CXC chemokine receptors.read more
Citations
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Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
TL;DR: This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.
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Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
TL;DR: Recent data on human mast cells is summarized, differences with murine mast cells are discussed, and new tools to study this increasingly meaningful cell type in humans are described.
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The Chemokine System in Innate Immunity
TL;DR: This review will highlight recent advances in understanding how chemokine function regulates the movement and positioning of innate immune cells at homeostasis and in response to acute inflammation, and then will review howChemokine-mediated innate immune cell trafficking plays an essential role in linking the innate and adaptive immune responses.
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Mast cell function: a new vision of an old cell.
TL;DR: This review summarizes the current knowledge of mast cell function in both normal and pathological conditions with regards to their regulation, phenotype and role.
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Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants
TL;DR: VCAM-1 signaling is a target for intervention by pharmacological agents and by antioxidants during inflammatory diseases because of its role as a scaffold for leukocyte migration and a trigger of endothelial signaling through NADPH oxidase-generated ROS.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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T-cell function and migration. Two sides of the same coin.
TL;DR: This review will concentrate on the migration of T cells, which are at the heart of most adaptive immune responses, since T cells respond to pathogens only on direct contact with pathogen-derived antigen.
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Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice
Bao Lu,Barbara J. Rutledge,Long Gu,Joseph Fiorillo,Nicholas W. Lukacs,Steven L. Kunkel,Robert J. North,Craig Gerard,Barrett J. Rollins +8 more
TL;DR: It is indicated that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses.
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Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
William A. Kuziel,Sharon J. Morgan,Tracey C. Dawson,Stephanie Griffin,Oliver Smithies,Klaus Ley,Nobuyo Maeda +6 more
TL;DR: Results demonstrate that CCR2 is a major regulator of induced macrophage trafficking in vivo and shows enhanced early accumulation and delayed clearance of neutrophils and eosinophils.
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Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog
Grace Cacalano,James Lee,Kristine Kikly,Ann M. Ryan,Sharon Pitts-Meek,Bruce Hultgren,William I. Wood,Mark W. Moore +7 more
TL;DR: This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.