Journal ArticleDOI
Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery
T.E. Goldberg,James M. Gold,R. Greenberg,S. Griffin,S C Schulz,David Pickar,Joel E. Kleinman,D.R. Weinberger +7 more
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TLDR
It is suggested that patients with schizophrenia perform systematically worse on cognitive measures than patients with affective disorders, which is consistent with their generally poorer outcome.Abstract:
Objective This study was designed to ascertain the degree and specificity of cognitive impairments in patients with schizophrenia and patients with affective disorders. Method Cognitive function was assessed with a neuropsychological test battery in consecutively admitted patients with schizophrenia (N = 57), unipolar depression (N = 29), and bipolar disorder (N = 16). Results The performance of the schizophrenic group was significantly below that of the groups with affective disorders on measures of attention and psychomotor speed, verbal and visual memory, and problem solving and abstraction. IQ was lower in the schizophrenic group and appeared to have deteriorated from a normal premorbid level that was not different from that of the affective disorder groups, as determined by the Wide Range Achievement Test--Revised reading test, a putative measure of premorbid intelligence. When IQ was controlled, differences between the groups in problem solving and visual memory remained. Psychiatric symptoms had a larger impact on test performance in the affective disorder groups than in the schizophrenic group. Conclusions These results suggest that patients with schizophrenia perform systematically worse on cognitive measures than patients with affective disorders, which is consistent with their generally poorer outcome. The results also indicate that schizophrenia and affective disorders are qualitatively distinguishable in neuropsychological terms, given differences in apparent intellectual deterioration, profiles of cognitive impairment, and associations between cognitive performance and psychopathology.read more
Citations
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Journal ArticleDOI
Neurocognitive Deficit in Schizophrenia: A Quantitative Review of the Evidence
TL;DR: The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
Journal ArticleDOI
Neurobiology of emotion perception II: Implications for major psychiatric disorders
TL;DR: It is suggested that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder.
Journal ArticleDOI
Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria
Michael F. Green,Keith H. Nuechterlein,James M. Gold,M Deanna,Jonathan D. Cohen,Susan M. Essock,Wayne S. Fenton,Fred Frese,Terry E. Goldberg,Robert K. Heaton,Richard S.E. Keefe,Robert S. Kern,Helena C. Kraemer,Ellen Stover,Daniel R. Weinberger,Steven Zalcman,Stephen R. Marder +16 more
TL;DR: In the first MATRICS consensus conference as discussed by the authors, the goal was to identify the cognitive domains that should be represented in a consensus cognitive battery and prioritize key criteria for selection of tests for the battery.
Approaching a Consensus Cognitive Battery for Clinical Trials in Schizophrenia: The NIMH-MATRICS Conference to Select Cognitive Domains and Test Criteria F. Green, Keith H. Nuechterlein, James M. Gold, Deanna M. Barch, Jonathan Cohen, Susan
Wayne S. Fenton,Fred Frese,Terry E. Goldberg,Robert K. Heaton,Helena C. Kraemer,Ellen Stover,Daniel R. Weinberger,Steven Zalcman,Stephen R. Marder +8 more
TL;DR: An overview of decisions from the first MATRICS consensus conference is presented, which constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.
Journal ArticleDOI
The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model
TL;DR: It is recommended that clinicians and researchers explore the presence of early adverse life events in adults with psychotic symptoms in order to ensure comprehensive formulations and appropriate treatment plans, and to further investigate the hypotheses generated by the TN model.
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