Journal ArticleDOI
Control of mitochondrial respiration. The contribution of the adenine nucleotide translocator depends on the ATP- and ADP-consuming enzymes
TLDR
The data clearly show that the sharing of control strength depends not only on the respiration rate but also on the complexity of the metabolic system.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1983-02-17. It has received 94 citations till now. The article focuses on the topics: Adenine nucleotide translocator & Pyruvate kinase.read more
Citations
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Journal ArticleDOI
Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure.
Edward J. Lesnefsky,Edward J. Lesnefsky,Shadi Moghaddas,Bernard Tandler,Janos Kerner,Charles L. Hoppel,Charles L. Hoppel +6 more
TL;DR: Mechanisms of mitochondrial-derived myocyte injury and the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) are addressed.
Journal ArticleDOI
Cardiolipins and biomembrane function
TL;DR: Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulates State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or metabolites.
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The ADP and ATP transport in mitochondria and its carrier
TL;DR: Different from some more specialised short reviews, here a general although not encyclopaedic survey of the function, metabolic role, structure and mechanism of the ADP/ATP transport in mitochondria is presented.
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Energy Thresholds in Brain Mitochondria POTENTIAL INVOLVEMENT IN NEURODEGENERATION
TL;DR: In this paper, the relative contribution of individual mitochondrial respiratory chain complexes to the control of NAD-linked substrate oxidative phosphorylation in synaptic mitochondria was examined, and it was shown that, in mitochondria of synaptic origin, complex I activity has a major control of oxidorylation, such that when a threshold of 25% inhibition is exceeded, energy metabolism is severely impaired.
Journal ArticleDOI
Obesity and type 2 diabetes.
TL;DR: The health benefits of weight loss and the efficacy of current weight loss strategies in obese persons with type 2 diabetes are evaluated and the results of lifestyle intervention trials designed to reduce conversion to type 1 diabetes in at-risk individuals are reviewed.
References
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Journal ArticleDOI
Quantification of the contribution of various steps to the control of mitochondrial respiration.
TL;DR: Inference titration studies were carried out in order to quantify the amount of control (control strength) exerted by different steps in oxidative phosphorylation on the rate of mitochondrial oxygen uptake.
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A linear steady-state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector.
TL;DR: It is concluded that for real systems the identification of the interaction sites of an effector with an enzymatic chain cannot be achieved by the simple crossover theorem, and even the Identification of “rate controlling” or “regulatory important” enzymes by means of c crossover must be done with great caution.
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Biochemical structure of mitonchodria. I. Intra-mitochondrial components and oxidative phosphorylation.
Philip Siekevitz,Van R. Potter +1 more
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Regulation of cellular metabolism by intracellular phosphate
TL;DR: It is postulated that the cellular respiratory rate and the NADH generation rate are regulated by [ ATP ] [ ADP ] · [ P i ] and not by the “energy charge” as defined by Atkinson (Biochemistry 7, 4030–4034, 1968).
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Equilibrium and Kinetic Studies of the Pyruvic Kinase Reaction
John T. McQuate,Merton F. Utter +1 more
TL;DR: Further studies on the pyruvic kinase reaction are presented including values for the equilibrium constant as a function of pH, the Michaelis constants for the reaction components, and maximal initial velocities for the forward and back reactions.