Journal ArticleDOI
Controlling soil transmitted helminths: Time to think inside the box?
TLDR
Using China as an example, the use of biogas technology as a solution to rural sanitation and energy problems is described, and its advantages over current strategies of mass drug administration and vaccination for STH control are highlighted.Abstract:
Soil-transmitted helminths (STH) refer to several parasitic nematode species that infect over 1 billion people worldwide. Infections with Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale cause significant morbidity in more than 450 million people, primarily children and pregnant women, resulting in over 39 million disability-adjusted life years lost. Considerable effort and resources have been, and continue to be, spent on top-down, medical-based programs to control STH infections, with little success. This review discusses the problems with these methods and proposes a new emphasis on sustainable, long-term investments in sanitation-based approaches using improved latrines (the “box”) to provide bottom-up, culturally appropriate, and economically desirable solutions to STH control in endemic areas. One such approach is the use of biogas technology. Waste undergoes fermentation in specially designed septic systems, generating a methane ga...read more
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Journal ArticleDOI
The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals
TL;DR: This scoping review assesses how in this context, ending the epidemic of the NTDs can impact and improve the prospects of attaining the SDGs.
Journal ArticleDOI
Anthelmintic Drug Discovery: Into the Future
TL;DR: The approaches and technologies in use to identify anthelmintics are reviewed and a number of drug discovery paradigms that may prove pivotal to the next half-century of anthel Mintic development are discussed.
Journal ArticleDOI
Effect of Poor Access to Water and Sanitation As Risk Factors for Soil-Transmitted Helminth Infection: Selectiveness by the Infective Route.
Adriana Echazú,Daniela Bonanno,Marisa Juarez,Silvana P. Cajal,Viviana Heredia,Silvia Caropresi,Rubén O. Cimino,Nicolás Caro,Paola Vargas,Gladys Paredes,Alejandro J. Krolewiecki +10 more
TL;DR: Lack of safe water and proper sanitation pose a risk of STH infections that is distinct according to the route of entry to the human host used by each of the STH species.
Journal ArticleDOI
Parasites, ghosts and mutualists: a relational geography of microbes for global health
TL;DR: This paper develops relational and multispecies approaches to health geography to examine situations of microbial excess, absence and controlled reintroduction on human relations with hookworms.
Journal ArticleDOI
Developing and evaluating health education learning package (HELP) to control soil-transmitted helminth infections among Orang Asli children in Malaysia
Ahmed K. Al-Delaimy,Ahmed K. Al-Delaimy,Hesham M. Al-Mekhlafi,Hesham M. Al-Mekhlafi,Yvonne A. L. Lim,Nabil A. Nasr,Hany Sady,Wahib M. Atroosh,Rohela Mahmud +8 more
TL;DR: A school-based health education learning package (HELP) was developed which displayed a significant impact in terms of reducing the intensity of all three main STH infections, as well as in reducing the prevalence of hookworm infections.
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