Journal ArticleDOI
Coordination chemistry of metals in medicine: target sites for bismuth
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TLDR
Bismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for other diseases as discussed by the authors, however, they exhibit a highly variable coordination number (3-10) and often an irregular coordination geometry.About:
This article is published in Coordination Chemistry Reviews.The article was published on 1999-05-01. It has received 249 citations till now. The article focuses on the topics: Coordination geometry & Coordination complex.read more
Citations
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Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
TL;DR: The OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain and serves as a potential alternative to viral vector for gene therapy.
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Drug delivery via the transferrin receptor-mediated endocytosis pathway
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New metal complexes as potential therapeutics.
TL;DR: Biological carriers conjugated to cisplatin analogs have improved specificity for tumor tissue, thereby reducing side effects and drug resistance, and metal-based chemotherapeutic compounds have the potential to modulate the biological properties of superoxide anion and nitric oxide.
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Platinum complexes as anticancer agents
TL;DR: This review focuses on recent advances in developing platinum anticancer agents with an emphasis on platinum coordination complexes, which exhibit promising pharmacological properties.
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Novel urea assisted hydrothermal synthesis of hierarchical BiVO4/Bi2O2CO3 nanocomposites with enhanced visible-light photocatalytic activity
TL;DR: In this article, a novel hydrothermal approach is developed for the first time to synthesize hierarchical BiVO4/Bi2O2CO3 nanocomposites with reactive crystalline facets using urea as a morphology mediator.
References
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Journal ArticleDOI
Acids and Bases: Hard acids prefer to associate with hard bases, and soft acids prefer to associate with soft bases.
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The crystal structure of urease from Klebsiella aerogenes
TL;DR: A surprisingly high structural similarity between the urease catalytic domain and that of the zinc-dependent adenosine deaminase reveals a remarkable example of active site divergence.
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The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.
TL;DR: The purified and characterized growth inhibitory factor (GIF) revealed a distinct subset of astrocytes in the gray matter that appears to be closely associated with neuronal perikarya and dendrites during AD, suggesting that GIF is down-regulated in the subset of Astrocytes during AD.
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Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation
TL;DR: A model is proposed in which luminal H. pylori secrete substances that mediate inflammation that is beneficial to the organism but ultimately deleterious for the host; in addition to tissue damage, inflammation also affects gastric secretory function.
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Three-dimensional structure of rabbit liver [Cd7]metallothionein-2a in aqueous solution determined by nuclear magnetic resonance.
Alexandre Arseniev,Peter Schultze,Erich Wörgötter,Werner Braun,Gerhard Wagner,Milan Vašák,Jeremias H. R. Kägi,Kurt Wüthrich +7 more
TL;DR: The improved structures of both domains show the previously noted differences relative to the recently published crystal structure of metallothionein-2a from rat liver, and the overall chirality of the polypeptide fold is right-handed for the beta-domain and left- handed for the alpha-domain.
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