Journal ArticleDOI
Copper-catalysed azide-alkyne cycloadditions (CuAAC): an update.
TLDR
The recent results described in the literature since 2010 are reviewed, classified according to the nature of the catalyst precursor: copper(I) or copper(II) salts or complexes, metallic or nano-particulated copper and several solid-supported copper systems.Abstract:
The reactions of organic azides and alkynes catalysed by copper species represent the prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed azide-alkyne cycloaddition), discovered in 2002, has been expanded since then to become an excellent tool in organic synthesis. In this contribution the recent results described in the literature since 2010 are reviewed, classified according to the nature of the catalyst precursor: copper(I) or copper(II) salts or complexes, metallic or nano-particulated copper and several solid-supported copper systems.read more
Citations
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Journal ArticleDOI
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology
Matthias Gehringer,Stefan Laufer +1 more
TL;DR: An overview of warheads-beyond α,β-unsaturated amides-recently used in the design of targeted covalent ligands is provided, with special emphasis on the discussion of reactivity and of case studies illustrating applications in medicinal chemistry and chemical biology.
Journal ArticleDOI
Photo-Triggered Click Chemistry for Biological Applications.
András Herner,Qing Lin +1 more
TL;DR: This chapter discusses in each cases the chemical and mechanistic background, the kinetics of the reactions and the biological applicability together with the limiting factors, with a focus on those that have shown broad utility in biological systems.
Journal ArticleDOI
Contemporary approaches to site-selective protein modification
Emily A. Hoyt,Pedro M. S. D. Cal,Bruno L. Oliveira,Bruno L. Oliveira,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +5 more
TL;DR: The goal of this Review is to provide a window through which to view the many opportunities created by novel protein modification techniques‚ and to act as an initial guide to help scientists find direction and form ideas in an ever-growing field.
Journal ArticleDOI
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications.
TL;DR: The ruthenium-catalyzed azide alkyne cycloaddition affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-Catalyzed reaction providing the 1,4-isomer.
Journal ArticleDOI
Targeting the N terminus for site-selective protein modification.
TL;DR: This Perspective provides an overview of N-terminal modification techniques and the chemical rationale governing each, along with their uses in a number of diverse biological applications.
References
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Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Journal ArticleDOI
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
Journal ArticleDOI
Cu-catalyzed azide-alkyne cycloaddition.
TL;DR: The basis for the unique properties and rate enhancement for triazole formation under Cu(1) catalysis should be found in the high ∆G of the reaction in combination with the low character of polarity of the dipole of the noncatalyzed thermal reaction, which leads to a considerable activation barrier.
Journal ArticleDOI
The growing impact of click chemistry on drug discovery.
TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
Journal ArticleDOI
Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles: From Theory to Applications
Sujit Kumar Ghosh,Tarasankar Pal +1 more
TL;DR: This paper presents a meta-analysis of four-Wave Mixing and its applications in nanofiltration, which shows clear trends in high-performance liquid chromatography and also investigates the role of nano-magnifying lens technology in this process.