Journal ArticleDOI
Corticotropin releasing factor (CRF)-stimulation test in normal controls and patients with disturbances of the hypothalamo-pituitary-adrenal axis
Reads0
Chats0
TLDR
Intravenous application of 100 µg synthetic ovine corticotropin releasing factor (CRF) led to stimulation of ACTH-secretion in nine normal controls, with a maximum 30 min after CRF.Abstract:
Intravenous application of 100 µg synthetic ovine corticotropin releasing factor (CRF) led to stimulation of ACTH-secretion in nine normal controls, with a maximum 30 min after CRF. Cortisol, corticosterone, cortisone and 11-deoxycortisol increased with a maximum at 60 min after CRF, whereas no rise was seen in aldosterone, 11-deoxycorticosterone, 17-α-hydroxyprogesterone, progesterone, DHEA-S and testosterone. The specificity of CRF-stimulation was also shown by unchanged TSH, LH, FSH, hGH, prolactin and thyroid hormone levels, als well as unchanged insulin and gastrin levels. No serious side-effects were observed during the test period and afterwards.read more
Citations
More filters
Journal ArticleDOI
Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression.
Journal ArticleDOI
Cushing's disease
TL;DR: The best treatment option of Cushing's disease is when the responsible corticotroph adenoma can be entirely removed by the trans-sphenoidal approach, with sufficient skill to preserve the normal anterior pituitary function.
Book ChapterDOI
The role of corticotropin-releasing hormone in the pathogenesis of Cushing`s disease, anorexia nervosa, alcoholism, affective disorders and dementia
TL;DR: The evidence presented in the chapter proposes that CRH integrates not only the hormonal but also the physiological and behavioral pattern in response to environmental and endogenous challenges perceived as stress and continuous alterations in the fine-tuned neuro-endocrine pathways result in overt psychopathology.
Journal ArticleDOI
Corticotropin-Releasing Factor (Ovine) and Vasopressin Exert a Synergistic Effect on Adrenocorticotropin Release in Man
TL;DR: The effects of ovine CRF, lysine vasopressin (LVP), and their interrelationships, and rat hypothalamic extract (HME), on ACTH and beta-endorphin release by human pituitary tumor cells from two patients with Nelson's syndrome and one with Cushing's disease and in vivo support the concept that in man, both ovineCRF and vasopressing factors are corticotropin-releasing factors which act synergistically.
Journal ArticleDOI
Corticotrophin releasing factor: responses in normal subjects and patients with disorders of the hypothalamus and pituitary
N. Lytras,Ashley B. Grossman,L. Perry,Susan Tomlin,J. A. H. Wass,D. H. Coy,A. V. Schally,L. H. Rees,G. M. Besser +8 more
TL;DR: The data suggest that normal or enhanced responses of hypercortisolaemic patients with Cushing's syndrome contrast with the complete inhibition of the responses to CRF‐41 in normal subjects given dexamethasone, suggesting these patients have a functional defect of ACTH secretion due to the failure of CRF to reach the corticotroph.
References
More filters
Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
Journal ArticleDOI
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Paul Brazeau,Wylie Vale,Roger Burgus,Nicholas Ling,Madalyn Butcher,Jean Rivier,Roger Guillemin +6 more
TL;DR: A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats.
Journal ArticleDOI
Isolation and properties of the FSH and LH-releasing hormone.
Andrew V. Schally,Akira Arimura,Yoshihiko Baba,R.M.G. Nair,Hisayuki Matsuo,Tommie W. Redding,Luciano Debeljuk +6 more
TL;DR: The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH- RH, and appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.
Journal ArticleDOI
In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*
TL;DR: The data suggest that CRF may play a physiological role in the regulation of the hypothalamic-pituitary-adrenal axis.
Related Papers (5)
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
New hypothalamic hormone, corticotropin-releasing factor, specifically stimulates the release of adrenocorticotropic hormone and cortisol in man
A. Grossman,A. Grossman,L. Perry,L. Perry,Andrew V. Schally,Andrew V. Schally,Lesley H. Rees,Lesley H. Rees,A. C. Nieuwenhuyzen Kruseman,A. C. Nieuwenhuyzen Kruseman,Susan Tomlin,Susan Tomlin,David H. Coy,David H. Coy,Ana Maria Comaru-Schally,Ana Maria Comaru-Schally,G. M. Besser,G. M. Besser +17 more