Costs of asthma are correlated with severity: a 1-yr prospective study
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TLDR
This is the first study in asthma to combine rigorous independent classification of grades of severity in statistically valid numbers of patients of grades receiving “real-world” treatment and followed-up prospectively for 1 yr, allowing severity to be accurately related to direct, indirect and intangible costs of asthma.Citations
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Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
Ian D. Pavord,Stephanie Korn,Peter H. Howarth,Eugene R. Bleecker,Roland Buhl,Oliver N. Keene,Hector Ortega,Pascal Chanez +7 more
TL;DR: Mepolizumab is an effective and well tolerated treatment that reduces the risk of asthma exacerbations in patients with severe eosinophilic asthma.
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The global burden of asthma.
TL;DR: The Global Initiative for Asthma has outlined a six-point patient management plan to address the effective handling of the increased number of patients in primary care, focusing on patient education, written treatment plans, and ongoing communication and review with patients and their providers.
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Dupilumab in persistent asthma with elevated eosinophil levels.
Sally E. Wenzel,Linda B. Ford,David S. Pearlman,Sheldon L. Spector,Lawrence Sher,Franck Skobieranda,Lin Wang,Stephane C. Kirkesseli,Ross E. Rocklin,Brian Bock,Jennifer D. Hamilton,Jeffrey Ming,Allen Radin,Neil Stahl,George D. Yancopoulos,Neil M.H. Graham,Gianluca Pirozzi +16 more
TL;DR: In patients with persistent, moderate-to-severe asthma and elevated eosinophil levels who used inhaled glucocorticoids and LABAs, dupilumab therapy, as compared with placebo, was associated with fewer asthma exacerbations when LABs and inhaled GLPAs were withdrawn, with improved lung function and reduced levels of Th2-associated inflammatory markers.
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Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Wendy C. Moore,Eugene R. Bleecker,Douglas Curran-Everett,Serpil C. Erzurum,Bill T. Ameredes,Leonard B. Bacharier,William J. Calhoun,Mario Castro,Kian Fan Chung,Melissa P. Clark,Raed A. Dweik,Anne M. Fitzpatrick,Benjamin Gaston,Mark Hew,Iftikhar Hussain,Nizar N. Jarjour,Elliot Israel,Bruce D. Levy,James Murphy,Stephen P. Peters,W. Gerald Teague,Deborah A. Meyers,William W. Busse,Sally E. Wenzel,Sally E. Wenzel,Sally E. Wenzel +25 more
TL;DR: Severe asthma is characterized by abnormal lung function that is responsive to bronchodilators, a history of sinopulmonary infections, persistent symptoms, and increased health care utilization.
References
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Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
An economic evaluation of asthma in the united states
TL;DR: The distribution of health care resources used for asthma in the United States was studied in order to lay the groundwork for further policy decisions aimed at reducing the economic burden of this disorder.
Journal ArticleDOI
Guidelines for the management of chronic obstructive pulmonary disease
TL;DR: In conclusion, guidelines may improve the management of COPD, but the main challenge is to ensure implementation.
Journal ArticleDOI
A National Estimate of the Economic Costs of Asthma
David H. Smith,Daniel C. Malone,Kenneth A. Lawson,Lynn J. Okamoto,Carmelina Battista,William B. Saunders +5 more
TL;DR: Findings from this study indicate that future asthma research and intervention efforts directed at hospitalizations and high-cost patients could help to decrease health care resource use and provide cost savings.
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