Journal ArticleDOI
Could controlling occult cytomegalovirus reactivation with prophylactic valganciclovir prevent immune checkpoint blockade-Related complications?
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This article is published in European Journal of Cancer.The article was published on 2021-06-18. It has received 2 citations till now. The article focuses on the topics: Immune checkpoint & Valganciclovir.read more
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External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition
Gunther Glehr,Paloma Riquelme,Jordi Yang Zhou,L Cordero,Hannah-Lou Schilling,Michael Kapinsky,Hans J. Schlitt,Edward K. Geissler,Ralph Burkhardt,Barbara Schmidt,Sebastian Haferkamp,James A. Hutchinson,Katharina Kronenberg +12 more
TL;DR: Externally validate the performance of 59 previously reported markers of irAE risk in a new cohort of 110 patients receiving Nivolumab and Ipilimumab therapy, finding that alone or combined, the discriminatory value of these routine clinical parameters and flow cytometry biomarkers was poor.
Journal ArticleDOI
Unexpectedly high seroprevalance of Kaposi's sarcoma-associated herpesvirus (HHV-8) in patients with stage IV melanoma.
Katharina Kronenberg,Jürgen J. Wenzel,Barbara Schmidt,James A. Hutchinson,Sebastian Haferkamp +4 more
TL;DR: In this article , the authors reported that a subset of patients at high risk of developing hepatitis could be identified prior to treatment by cytomegalovirus (CMV)-seropositivity and expansion of effector memory CD4+ T cells (TEM) in peripheral blood.
References
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Journal ArticleDOI
Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): a randomised, double-blind, placebo-controlled, phase 2 trial
Lisa Zimmer,Elisabeth Livingstone,Jessica C. Hassel,Michael Fluck,Thomas Eigentler,Carmen Loquai,Sebastian Haferkamp,Ralf Gutzmer,Friedegund Meier,Peter Mohr,Axel Hauschild,Bastian Schilling,Christian Menzer,Felix Kieker,Edgar Dippel,Alexander Rösch,Jan-Christoph Simon,Beate Conrad,Silvia Körner,Christine Windemuth-Kieselbach,Leonora Schwarz,Claus Garbe,Jürgen C. Becker,Dirk Schadendorf,Carola Berking,Rudolf A. Herbst,Uwe M. Martens,Sabine Sell,Rudolf Stadler,Patrick Terheyden,Jochen Utikal +30 more
TL;DR: The results presented in this report reflect the prespecified interim analysis of recurrence-free survival after 90 events had been reported, and the hazard ratio for recurrence for the nivolumab plus ipilimumab group versus placebo group was 0·23 (97·5% CI 0·12-0·45; p<0·0001).
Journal ArticleDOI
A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis
Douglas B. Johnson,Wyatt J. McDonnell,Paula I. Gonzalez-Ericsson,Rami N. Al-Rohil,Rami N. Al-Rohil,Bret C. Mobley,Joe-Elie Salem,Joe-Elie Salem,Daniel Y. Wang,Violeta Sanchez,Yu Wang,Cody A. Chastain,Kristi Barker,Yan Liang,Sarah Warren,Joseph M. Beechem,Alexander M. Menzies,Martin Tio,Georgina V. Long,Justine V. Cohen,Amanda C. Guidon,Meabh O'Hare,Sunandana Chandra,Akansha Chowdhary,Bénédicte Lebrun-Vignes,Simone M. Goldinger,Elisabeth J. Rushing,Elizabeth I. Buchbinder,Simon Mallal,Chanjuan Shi,Yaomin Xu,Javid Moslehi,Melinda E. Sanders,Jeffrey A. Sosman,Justin M. Balko +34 more
TL;DR: A fatal case of encephalitis arising during anti-programmed cell death receptor 1 therapy in a patient with metastatic melanoma is reported, and deep molecular profiling of a single case of severe anti-PD-1-induced neurotoxicity shows oligoclonal cytotoxic memory CD4+ T cells are enriched in inflamed brain tissue.
Journal ArticleDOI
Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditis.
Elisabetta Caselli,Maria Chiara Zatelli,Roberta Rizzo,Sabrina Benedetti,Debora Martorelli,Giorgio Trasforini,Enzo Cassai,Ettore C. degli Uberti,Dario Di Luca,Riccardo Dolcetti +9 more
TL;DR: A potential role for HHV-6 (possibly variant A) in the development or triggering of HT is suggested, as thyrocytes from HT FNA displayed a 100-fold higher HHv-6 DNA load compared to infiltrating lymphocytes.
Journal ArticleDOI
Autoimmune Colitis and Subsequent CMV-induced Hepatitis After Treatment With Ipilimumab.
TL;DR: In conclusion, cytomegalovirus reactivation should be included in the differential in patients under immunotherapy with checkpoint inhibitors and has to be considered as a cause for morbidity.
Journal ArticleDOI
Cytomegalovirus reactivation in patients with refractory checkpoint inhibitor-induced colitis.
Cindy Franklin,Isabelle Rooms,Melanie Fiedler,Henning Reis,Laura Milsch,Saskia Herz,Elisabeth Livingstone,Lisa Zimmer,Kurt Werner Schmid,Ulf Dittmer,Dirk Schadendorf,Bastian Schilling,Bastian Schilling +12 more
TL;DR: This report on CMV reactivation during management of checkpoint inhibitor-induced colitis emphasises the need for repetitive diagnostic measures in treatment-refractory irColitis.