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Paula I. Gonzalez-Ericsson
Researcher at Vanderbilt University Medical Center
Publications - 39
Citations - 1994
Paula I. Gonzalez-Ericsson is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 13, co-authored 27 publications receiving 1030 citations. Previous affiliations of Paula I. Gonzalez-Ericsson include Vanderbilt University.
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Journal ArticleDOI
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group Part 2 TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Shona Hendry,Roberto Salgado,Thomas Gevaert,Prudence A. Russell,Prudence A. Russell,Thomas John,Thomas John,Bibhusal Thapa,Michael Christie,Koen Van de Vijver,Monica V. Estrada,Paula I. Gonzalez-Ericsson,Melinda E. Sanders,Benjamin Solomon,Cinzia Solinas,Gert Van den Eynden,Yves Allory,Yves Allory,Matthias Preusser,Johannes A. Hainfellner,Giancarlo Pruneri,Andrea Vingiani,Sandra Demaria,Fraser Symmans,Paolo Nuciforo,Laura Comerma,E. A. Thompson,Sunil R. Lakhani,Sunil R. Lakhani,Seong Rim Kim,Stuart J. Schnitt,Cecile Colpaert,Christos Sotiriou,Stefan J. Scherer,Michail Ignatiadis,Sunil S. Badve,Robert H. Pierce,Giuseppe Viale,Nicolas Sirtaine,Frédérique Penault-Llorca,Tomohagu Sugie,Susan Fineberg,Soonmyung Paik,Ashok Srinivasan,Andrea L. Richardson,Yihong Wang,Yihong Wang,Ewa Chmielik,Jane E. Brock,Douglas B. Johnson,Justin M. Balko,Stephan Wienert,Veerle Bossuyt,Stefan Michiels,Nils Ternès,Nicole Burchardi,Stephen J Luen,Stephen J Luen,Peter Savas,Peter Savas,Frederick Klauschen,Peter H. Watson,Peter H. Watson,Brad H. Nelson,Brad H. Nelson,Carmen Criscitiello,Sandra A O'Toole,Denis Larsimont,Roland de Wind,Giuseppe Curigliano,Fabrice Andre,Magali Lacroix-Triki,Mark van de Vijver,Federico Rojo,Giuseppe Floris,Shahinaz Bedri,Joseph A. Sparano,David L. Rimm,Torsten O. Nielsen,Zuzana Kos,Stephen M. Hewitt,Baljit Singh,Gelareh Farshid,Gelareh Farshid,Sibylle Loibl,Kimberly H. Allison,Nadine Tung,Sylvia Adams,Karen Willard-Gallo,Hugo M. Horlings,Leena Gandhi,Leena Gandhi,Andre L. Moreira,Fred R. Hirsch,Maria Vittoria Dieci,Maria Urbanowicz,Iva Brcic,Konstanty Korski,Fabien Gaire,Hartmut Koeppen,Amy C. Y. Lo,Amy C. Y. Lo,Jennifer M. Giltnane,Marlon Rebelatto,Keith Steele,Jiping Zha,Kenneth Emancipator,Jonathan Juco,Carsten Denkert,Jorge S. Reis-Filho,Sherene Loi,Stephen B. Fox +111 more
TL;DR: Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
Journal ArticleDOI
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research
Shona Hendry,Roberto Salgado,Thomas Gevaert,Prudence A. Russell,Prudence A. Russell,Thomas John,Thomas John,Bibhusal Thapa,Michael Christie,Koen Van de Vijver,Monica V. Estrada,Paula I. Gonzalez-Ericsson,Melinda E. Sanders,Benjamin sss Solomon,Cinzia Solinas,Gert Van den Eynden,Yves Allory,Yves Allory,Matthias Preusser,Johannes A. Hainfellner,Giancarlo Pruneri,Andrea Vingiani,Sandra Demaria,Fraser Symmans,Paolo Nuciforo,Laura Comerma,E. A. Thompson,Sunil R. Lakhani,Sunil R. Lakhani,Seong-Rim Kim,Stuart J. Schnitt,Cecile Colpaert,Christos Sotiriou,Stefan J. Scherer,Michail Ignatiadis,Sunil Badve,Robert H. Pierce,Giuseppe Viale,Nicolas Sirtaine,Frédérique Penault-Llorca,Tomohagu Sugie,Susan Fineberg,Soonmyung Paik,Ashok Srinivasan,Andrea L. Richardson,Yihong Wang,Yihong Wang,Ewa Chmielik,Jane E. Brock,Douglas B. Johnson,Justin M. Balko,Stephan Wienert,Veerle Bossuyt,Stefan Michiels,Nils Ternès,Nicole Burchardi,Stephen J Luen,Stephen J Luen,Peter Savas,Peter Savas,Frederick Klauschen,Peter H. Watson,Brad H. Nelson,Carmen Criscitiello,Sandra A O'Toole,Denis Larsimont,Roland de Wind,Giuseppe Curigliano,Fabrice Andre,Magali Lacroix-Triki,Mark van de Vijver,Federico Rojo,Giuseppe Floris,Shahinaz Bedri,Joseph A. Sparano,David L. Rimm,Torsten O. Nielsen,Zuzana Kos,Stephen M. Hewitt,Baljit Singh,Gelareh Farshid,Sibylle Loibl,Kimberly H. Allison,Nadine Tung,Sylvia Adams,Karen Willard-Gallo,Hugo M. Horlings,Leena Gandhi,Leena Gandhi,Andre L. Moreira,Fred R. Hirsch,Maria Vittoria Dieci,Maria Urbanowicz,Iva Brcic,Konstanty Korski,Fabien Gaire,Hartmut Koeppen,Amy C. Y. Lo,Amy C. Y. Lo,Jennifer M. Giltnane,Marlon Rebelatto,Keith Steele,Jiping Zha,Kenneth Emancipator,Jonathan Juco,Carsten Denkert,Jorge S. Reis-Filho,Sherene Loi,Stephen B. Fox +108 more
TL;DR: In this paper, a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, was proposed.
Journal ArticleDOI
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Na Luo,Na Luo,Mellissa J. Nixon,Paula I. Gonzalez-Ericsson,Violeta Sanchez,Susan R. Opalenik,Huili Li,Cynthia A. Zahnow,Michael L. Nickels,Fei Liu,Mohammed N. Tantawy,Melinda E. Sanders,H. Charles Manning,Justin M. Balko +13 more
TL;DR: Targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expression and the recruitment of CD8+ T cells.
Journal ArticleDOI
The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice
Paula I. Gonzalez-Ericsson,Elisabeth Specht Stovgaard,Luz F. Sua,Emily Reisenbichler,Zuzana Kos,Jodi M. Carter,Stefan Michiels,John Le Quesne,John Le Quesne,Torsten O. Nielsen,Anne-Vibeke Lænkholm,Stephen B. Fox,Stephen B. Fox,Julien Adam,John M. S. Bartlett,John M. S. Bartlett,David L. Rimm,Cecily Quinn,Dieter Peeters,Maria Vittoria Dieci,Anne Vincent-Salomon,Ian A. Cree,Akira I Hida,Justin M. Balko,Harry R Haynes,Harry R Haynes,Isabel Frahm,Gabriela Acosta‐Haab,Marcelo Luiz Balancin,Enrique Bellolio,Wentao Yang,Pawan Kirtani,Tomoharu Sugie,Anna Ehinger,Carlos A. Castaneda,Marleen Kok,Heather L. McArthur,Kalliopi P. Siziopikou,Sunil Badve,Susan Fineberg,Allen M. Gown,Giuseppe Viale,Stuart J. Schnitt,Stuart J. Schnitt,Giancarlo Pruneri,Frédérique Penault-Llorca,Stephen M. Hewitt,E. Aubrey Thompson,Kimberly H. Allison,William Fraser Symmans,Andrew M. Bellizzi,Edi Brogi,David A Moore,Denis Larsimont,Deborah A. Dillon,Alexander J. Lazar,Huang-Chun Lien,Matthew P. Goetz,Glenn Broeckx,Khalid El Bairi,Nadia Harbeck,Ashley Cimino-Mathews,Christos Sotiriou,Sylvia Adams,Shi‐wei Liu,Sibylle Loibl,I-Chun Chen,Sunil R. Lakhani,Jonathan Juco,Carsten Denkert,Elizabeth F Blackley,Sandra Demaria,Roberto A. Leon-Ferre,Oleg Gluz,Dimitrios Zardavas,Kenneth Emancipator,Scott Ely,Sherene Loi,Sherene Loi,Roberto Salgado,Melinda E. Sanders +80 more
TL;DR: A risk‐management framework is proposed that may help mitigate the risks of suboptimal patient selection for immuno‐therapeutic approaches in clinical trials and daily practice based on combined TILs/PD‐L1 assessment in BC.
Journal ArticleDOI
A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis
Douglas B. Johnson,Wyatt J. McDonnell,Paula I. Gonzalez-Ericsson,Rami N. Al-Rohil,Rami N. Al-Rohil,Bret C. Mobley,Joe-Elie Salem,Joe-Elie Salem,Daniel Y. Wang,Violeta Sanchez,Yu Wang,Cody A. Chastain,Kristi Barker,Yan Liang,Sarah Warren,Joseph M. Beechem,Alexander M. Menzies,Martin Tio,Georgina V. Long,Justine V. Cohen,Amanda C. Guidon,Meabh O'Hare,Sunandana Chandra,Akansha Chowdhary,Bénédicte Lebrun-Vignes,Simone M. Goldinger,Elisabeth J. Rushing,Elizabeth I. Buchbinder,Simon Mallal,Chanjuan Shi,Yaomin Xu,Javid Moslehi,Melinda E. Sanders,Jeffrey A. Sosman,Justin M. Balko +34 more
TL;DR: A fatal case of encephalitis arising during anti-programmed cell death receptor 1 therapy in a patient with metastatic melanoma is reported, and deep molecular profiling of a single case of severe anti-PD-1-induced neurotoxicity shows oligoclonal cytotoxic memory CD4+ T cells are enriched in inflamed brain tissue.