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Bret C. Mobley
Researcher at Vanderbilt University Medical Center
Publications - 84
Citations - 2955
Bret C. Mobley is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 23, co-authored 66 publications receiving 2323 citations. Previous affiliations of Bret C. Mobley include Veterans Health Administration & Stanford University.
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Journal ArticleDOI
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm,Dominik Sturm,Brent A. Orr,Umut H. Toprak,Volker Hovestadt,David T.W. Jones,David Capper,David Capper,Martin Sill,Ivo Buchhalter,Paul A. Northcott,Irina Leis,Marina Ryzhova,Christian Koelsche,Christian Koelsche,Elke Pfaff,Elke Pfaff,Sariah Allen,Gnanaprakash Balasubramanian,Barbara C. Worst,Barbara C. Worst,Kristian W. Pajtler,Sebastian Brabetz,Pascal Johann,Pascal Johann,Felix Sahm,Felix Sahm,Jüri Reimand,Jüri Reimand,Alan Mackay,Diana Carvalho,Marc Remke,Joanna J. Phillips,Arie Perry,Cynthia Cowdrey,Rachid Drissi,Maryam Fouladi,Felice Giangaspero,Maria Łastowska,Wiesława Grajkowska,Wolfram Scheurlen,Torsten Pietsch,Christian Hagel,Johannes Gojo,Daniela Lötsch,Walter Berger,Irene Slavc,Christine Haberler,Anne Jouvet,Stefan Holm,Silvia Hofer,Marco Prinz,Catherine Keohane,Iris Fried,Christian Mawrin,David Scheie,Bret C. Mobley,Matthew Schniederjan,Mariarita Santi,Anna Maria Buccoliero,Sonika Dahiya,Christof M. Kramm,André O. von Bueren,Katja von Hoff,Stefan Rutkowski,Christel Herold-Mende,Michael C. Frühwald,Till Milde,Till Milde,Martin Hasselblatt,Pieter Wesseling,Pieter Wesseling,Jochen Rößler,Ulrich Schüller,Martin Ebinger,Jens Schittenhelm,Stephan Frank,Rainer Grobholz,Istvan Vajtai,Volkmar Hans,Reinhard Schneppenheim,Karel Zitterbart,V. Peter Collins,Eleonora Aronica,Pascale Varlet,Stéphanie Puget,Christelle Dufour,Jacques Grill,Dominique Figarella-Branger,Marietta Wolter,Martin U. Schuhmann,Tarek Shalaby,Michael A. Grotzer,Timothy E. Van Meter,Camelia M. Monoranu,Jörg Felsberg,Guido Reifenberger,Matija Snuderl,Lynn Ann Forrester,Jan Koster,Rogier Versteeg,Richard Volckmann,Peter van Sluis,Stephan Wolf,Tom Mikkelsen,Amar Gajjar,Kenneth Aldape,Andrew S. Moore,Michael D. Taylor,Chris Jones,Nada Jabado,Matthias A. Karajannis,Roland Eils,Matthias Schlesner,Peter Lichter,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,David W. Ellison,Andrey Korshunov,Andrey Korshunov,Marcel Kool +122 more
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
Journal ArticleDOI
NFKBIA Deletion in Glioblastomas
Markus Bredel,Denise M. Scholtens,Ajay Yadav,Angel A. Alvarez,Jaclyn J. Renfrow,James P. Chandler,Irene L.Y. Yu,Maria Stella Carro,Fangping Dai,Michael J. Tagge,Roberto Ferrarese,Claudia Bredel,Heidi S. Phillips,Paul J. Lukac,Pierre A. Robe,Pierre A. Robe,Astrid Weyerbrock,Hannes Vogel,Steven Dubner,Bret C. Mobley,Xiaolin He,Adrienne C. Scheck,Branimir I. Sikic,Kenneth Aldape,Arnab Chakravarti,Griffith R. Harsh +25 more
TL;DR: Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival.
Journal ArticleDOI
The Polar T1 Interface Is Linked to Conformational Changes that Open the Voltage-Gated Potassium Channel
Daniel L. Minor,Yu-Fung Lin,Bret C. Mobley,Abigail Avelar,Yuh Nung Jan,Lily Yeh Jan,James M. Berger +6 more
TL;DR: Together, data suggest that structural changes involving the buried polar T1 surfaces play a key role in the conformational changes leading to channel opening, and an isosteric mutation in this interface causes surprisingly little structural alteration.
Journal ArticleDOI
Loss of SMARCB1/INI1 expression in poorly differentiated chordomas.
Bret C. Mobley,Bret C. Mobley,Jesse K. McKenney,Charles D. Bangs,Katherine Callahan,Kristen W. Yeom,Reinhard Schneppenheim,Melanie G. Hayden,Athena M. Cherry,Murat Gokden,Michael S. B. Edwards,Paul G. Fisher,Hannes Vogel +12 more
TL;DR: All poorly differentiated chordomas in this series showed the absence of SMARCB1/INI1 expression, and were reliably distinguished from AT/RTs, clinically by their characteristic primary sites of origin and pathologically by strong nuclear brachyury expression.
Journal ArticleDOI
IGF-I prevents glutamate-induced motor neuron programmed cell death
TL;DR: The results suggest that the dose and timing of IGF-I administration are critical for producing a neuroprotective effect, and also suggest that both the MAPK and PI-3K/Akt pathways can promote the survival of motor neurons.