Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation
Roy C. P. Kerckhoffs,Maxwell Lewis Neal,Quan Gu,James B. Bassingthwaighte,Jeffrey H. Omens,Andrew D. McCulloch +5 more
TLDR
A novel, robust method to couple finite element models of cardiac mechanics to systems models of the circulation, independent of cardiac phase is presented, encompassing levels from cell to system.Abstract:
In this study we present a novel, robust method to couple finite element (FE) models of cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac phase. For each time step through a cardiac cycle, left and right ventricular pressures were calculated using ventricular compliances from the FE and CIRC models. These pressures served as boundary conditions in the FE and CIRC models. In succeeding steps, pressures were updated to minimize cavity volume error (FE minus CIRC volume) using Newton iterations. Coupling was achieved when a predefined criterion for the volume error was satisfied. Initial conditions for the multi-scale model were obtained by replacing the FE model with a varying elastance model, which takes into account direct ventricular interactions. Applying the coupling, a novel multi-scale model of the canine cardiovascular system was developed. Global hemodynamics and regional mechanics were calculated for multiple beats in two separate simulations with a left ventricular ischemic region and pulmonary artery constriction, respectively. After the interventions, global hemodynamics changed due to direct and indirect ventricular interactions, in agreement with previously published experimental results. The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system.read more
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Journal ArticleDOI
Patient-Specific Modeling of Blood Flow and Pressure in Human Coronary Arteries
Hyung J. Kim,Irene E. Vignon-Clementel,Jessica S. Coogan,C. A. Figueroa,Kenneth E. Jansen,Charles A. Taylor +5 more
TL;DR: A method that predicts coronary flow and pressure of three-dimensional epicardial coronary arteries by considering models of the heart and arterial system and the interactions between the two models was developed.
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Whole-Heart Modeling Applications to Cardiac Electrophysiology and Electromechanics
TL;DR: The goal of this review is to assess the existing state-of-the-art in whole-heart modeling and the plethora of its applications in cardiac research and the future developments envisioned for the field of cardiac simulation and modeling.
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On coupling a lumped parameter heart model and a three-dimensional finite element aorta model.
Hyun Jin Kim,Irene E. Vignon-Clementel,C. A. Figueroa,John F. LaDisa,Kenneth E. Jansen,Jeffrey A. Feinstein,Charles A. Taylor +6 more
TL;DR: This work considers interactions between the heart and arterial system by utilizing a lumped parameter heart model as an inflow boundary condition for three-dimensional finite element simulations of aortic blood flow and vessel wall dynamics and obtains physiologically realisticAortic flow and pressure waveforms.
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The Foundational Model of Anatomy Ontology
TL;DR: The Foundational Model of Anatomy (FMA) ontology is being developed to fill the need for a generalizable anatomy ontology, which can be used and adapted by any computer-based application that requires anatomical information.
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External tissue support and fluid-structure simulation in blood flows.
Philippe Moireau,Philippe Moireau,Nan Xiao,Matteo Astorino,Matteo Astorino,C. A. Figueroa,Dominique Chapelle,Charles A. Taylor,Jean-Frédéric Gerbeau,Jean-Frédéric Gerbeau +9 more
TL;DR: This work proposes to model the effect of external tissues by introducing viscoelastic support conditions along the artery wall, with two—possibly distributed—parameters that can be adjusted to mimic the response of various physiological tissues.
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