COVID-19 cytokine storm: the interplay between inflammation and coagulation.
Ricardo J. José,Ari Manuel +1 more
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This article is published in The Lancet Respiratory Medicine.The article was published on 2020-04-27 and is currently open access. It has received 973 citations till now. The article focuses on the topics: Cytokine storm.read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Longitudinal analyses reveal immunological misfiring in severe COVID-19.
Carolina Lucas,Patrick Wong,Jon Klein,Tiago B. R. Castro,Julio Silva,Maria E. Sundaram,Mallory K. Ellingson,Tianyang Mao,Ji Eun Oh,Benjamin Israelow,Takehiro Takahashi,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Subhasis Mohanty,Haowei Wang,Anne L. Wyllie,Chantal B.F. Vogels,Rebecca Earnest,Sarah Lapidus,Isabel M. Ott,Adam J. Moore,M. Catherine Muenker,John Fournier,Melissa Campbell,Camila D. Odio,Arnau Casanovas-Massana,Roy S. Herbst,Albert C. Shaw,Ruslan Medzhitov,Ruslan Medzhitov,Wade L. Schulz,Nathan D. Grubaugh,Charles S. Dela Cruz,Shelli F. Farhadian,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +39 more
TL;DR: A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease, as well as early immune signatures that correlate with divergent disease trajectories.
Journal ArticleDOI
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.
Hannah Peckham,Nina M. de Gruijter,Charles Raine,Anna Radziszewska,Coziana Ciurtin,Lucy R. Wedderburn,Lucy R. Wedderburn,Lucy R. Wedderburn,Elizabeth C. Rosser,Kate Webb,Kate Webb,Claire T Deakin,Claire T Deakin,Claire T Deakin +13 more
TL;DR: A meta-analysis of 3,111,714 reported global cases shows that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission and higher odds of death compared to females.
Journal ArticleDOI
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
Rajendra Karki,Bhesh Raj Sharma,Shraddha Tuladhar,Evan P. Williams,Lillian Zalduondo,Parimal Samir,Min Zheng,Balamurugan Sundaram,Balaji Banoth,R. K. Subbarao Malireddi,Patrick Schreiner,Geoffrey Neale,Peter Vogel,Richard Webby,Colleen B. Jonsson,Thirumala-Devi Kanneganti +15 more
TL;DR: It is suggested that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.
Journal ArticleDOI
COVID-19 and diabetes mellitus: from pathophysiology to clinical management.
TL;DR: Evidence suggests that insulin and dipeptidyl peptidase 4 inhibitors can be used safely in patients with diabetes mellitus and COVID-19; metformin and sodium–glucose cotransporter 2 inhibitors might need to be withdrawn in patients at high risk of severe disease.
References
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Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.
TL;DR: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronvirus pneumonia (NCP) cases were a concern.
Journal ArticleDOI
Vorapaxar in the secondary prevention of atherothrombotic events
David A. Morrow,Eugene Braunwald,Marc P. Bonaca,Sebastian F. Ameriso,Anthony J. Dalby,Mary Polly Fish,Keith A.A. Fox,Leslie J. Lipka,Xuan Liu,Jose C. Nicolau,A.J. Oude Ophuis,Ernesto Paolasso,Benjamin M. Scirica,Jindrich Spinar,Pierre Théroux,Stephen D. Wiviott,John Strony,Sabina A. Murphy +17 more
TL;DR: Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy, however, it increased therisk of moderate or severe bleeding, including intracranial hemorrhage.
Journal ArticleDOI
Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome.
G. Umberto Meduri,Gary Kohler,Stacey Headley,Elizabeth A. Tolley,Frankie Stentz,Arnold E. Postlethwaite +5 more
TL;DR: In this paper, the authors investigated the relationship between degree and duration of lung inflammation and progression of fibroproliferation in non-resolving acute respiratory distress disorder (ARDS), and found that an unfavorable outcome is associated with an initial, exaggerated, pulmonaiy inflammatory response that persists unabated over time.
Journal ArticleDOI
H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.
TL;DR: Investigation of the cellular immune response to infection in the mouse lung by flow cytometry shows that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP virus infection.
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