CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool
Carolyn Brokowski,Mazhar Adli +1 more
TLDR
It is held that moral decision making should evolve as the science of genomic engineering advances and it would be reasonable for national and supranational legislatures to consider evidence-based regulation of certain CRISPR applications for the betterment of human health and progress.About:
This article is published in Journal of Molecular Biology.The article was published on 2019-01-04 and is currently open access. It has received 106 citations till now. The article focuses on the topics: CRISPR.read more
Citations
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Correction of a pathogenic gene mutation in human embryos
Hong Ma,Nuria Marti-Gutierrez,Park Sw,Jun Wu,Young Hee Lee,Keiichiro Suzuki,Amy Koski,Ji D,Tomonari Hayama,Riffat Ahmed,Hayley Darby,Van Dyken C,Yang Li,Kang E,Park Ar,Kim D,Sangtae Kim,Gong J,Ying Gu,David Battaglia,Sacha A. Krieg,David M. Lee,Wu Dh,Don P. Wolf,Stephen B. Heitner,Belmonte Jci,Paula Amato,Jin-Soo Kim,Sanjiv Kaul,Shoukhrat Mitalipov +29 more
Additional file 2: of A comprehensive survey of the mutagenic impact of common cancer cytotoxics
Bernadett Szikriszt,Ádám Póti,Orsolya Pipek,Marcin Krzystanek,Nnennaya Kanu,János Molnár,Dezső Ribli,Zoltán Szeltner,Gábor E. Tusnády,István Csabai,Zoltan Szallasi,Charles Swanton,Dávid Szüts +12 more
TL;DR: This study provides support for the use of cell line mutagenesis assays to validate or predict the mutagenic effect of environmental and iatrogenic exposures, and suggests genetic reversion due to cisplatin-induced mutations as a distinct mechanism for developing resistance.
References
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Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong,Le Cong,F. Ann Ran,F. Ann Ran,David M. Cox,David M. Cox,Shuailiang Lin,Shuailiang Lin,Robert P. J. Barretto,Naomi Habib,Patrick D. Hsu,Patrick D. Hsu,Xuebing Wu,Wenyan Jiang,Luciano A. Marraffini,Feng Zhang +15 more
TL;DR: The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage as discussed by the authors.
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong,F. A. Ran,David Benjamin Turitz Cox,Shuailiang Lin,Robert P. J. Barretto,Naomi Habib,Patrick D. Hsu,Xuebing Wu,Wenyan Jiang,Luciano A. Marraffini,Feng Zhang +10 more
TL;DR: Two different type II CRISPR/Cas systems are engineered and it is demonstrated that Cas9 nucleases can be directed by short RNAs to induce precise cleavage at endogenous genomic loci in human and mouse cells, demonstrating easy programmability and wide applicability of the RNA-guided nuclease technology.