Crystal structure of phosphoserine phosphatase from Methanococcus jannaschii, a hyperthermophile, at 1.8 A resolution.
TLDR
This PSP structure appears to be a good model for the closed conformation of P-type ATPase, and may resemble the phosphoserine bound state or the state after autodephosphorylation.About:
This article is published in Structure.The article was published on 2001-01-01 and is currently open access. It has received 133 citations till now. The article focuses on the topics: Phosphoserine phosphatase & Rossmann fold.read more
Citations
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Journal ArticleDOI
Serine/Threonine Phosphatases: Mechanism through Structure
TL;DR: Biochemical and structural investigations that advance the mechanistic understanding of the three major classes of PSPs are discussed, with a focus on PP2A.
Journal ArticleDOI
Structural basis for control by phosphorylation.
Journal ArticleDOI
Structure and mechanism of Na,K-ATPase: functional sites and their interactions
TL;DR: Evidence is related on functional sites of Na,K-ATPase for the substrate (ATP), the essential cofactor (Mg(2+) ions), and the transported cations (Na(+) and K(+)) to the molecular structure to address the central questions of mechanism of active cation transport by all P-type cation pumps.
Journal ArticleDOI
A structural perspective of CTD function
TL;DR: Structural and functional studies of CTD-binding and -modifying proteins now reveal some of the mechanisms underlying CTD function, and the basis for CTD specificity of these enzymes remains to be understood.
Journal ArticleDOI
Evolutionary Genomics of the HAD Superfamily: Understanding the Structural Adaptations and Catalytic Diversity in a Superfamily of Phosphoesterases and Allied Enzymes
TL;DR: A comprehensive analysis of the HAD superfamily is presented that identifies their unique structural features and provides a detailed classification of the entire superfamily and suggests that at the highest level the HADS is unified with several other superfamilies, namely the DHH, receiver, von Willebrand A, TOPRIM, classical histone deacetylases and PIN/FLAP nuclease domains.
References
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Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
TL;DR: The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell.
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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Improved methods for building protein models in electron density maps and the location of errors in these models.
TL;DR: In this paper, the authors describe strategies and tools that help to alleviate this problem and simplify the model-building process, quantify the goodness of fit of the model on a per-residue basis and locate possible errors in peptide and side-chain conformations.
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Protein structure comparison by alignment of distance matrices
Liisa Holm,Chris Sander +1 more
TL;DR: A novel algorithm (DALI) for optimal pairwise alignment of protein structures that identifies structural resemblances and common structural cores accurately and sensitively, even in the presence of geometrical distortions is developed.
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The role of glutamate neurotoxicity in hypoxic- ischemic neuronal death
Dennis W. Choi,Steven M. Rothman +1 more
TL;DR: A critical question has been why brain, more than mostother tissues, is so vulnerable to hypoxic-ischemic insults, and at least some of this special vulnerability may be accounted for by the central neurotoxicity of the endogenous excitatory