Journal ArticleDOI
Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection.
Uma Santhanam,Cecilia Avila,Roberto Romero,Huguette Viguet,Nobuo Ida,Shingou Sakurai,Pravinkumar B. Sehgal +6 more
TLDR
The participation of interleukin-6 in the pathophysiology of normal and abnormal human parturition was evaluated by determining IL-6 concentrations in amniotic fluid using the B9 hybridoma growth factor assay and a monoclonal antibody-based ELISA.About:
This article is published in Cytokine.The article was published on 1991-03-01. It has received 152 citations till now. The article focuses on the topics: Premature rupture of membranes & Amniotic fluid.read more
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Book ChapterDOI
Interleukin-6 in biology and medicine
TL;DR: Application of IL-6 is promising in cancer treatment as well as in treatment of radiation- or chemotherapy-induced myelosuppression and the cell biology of the intracellular events that link transduction to gene regulation is an important area, and work on these topics helps to understand such phenomena as multifunction of IL -6 and bidirectional effects of cell growth depending on the cell type.
Journal ArticleDOI
A review of premature birth and subclinical infection
TL;DR: Results support the hypothesis that premature birth results in part from infection caused by genital tract bacteria, and research efforts must be prioritized to determine the role of infection and the appropriate prevention of this cause of prematurity.
Journal ArticleDOI
Cytokine balance in the lungs of patients with acute respiratory distress syndrome.
William Y. Park,Richard B. Goodman,Kenneth P. Steinberg,John T. Ruzinski,Frank Radella,David R. Park,Jérôme Pugin,Shawn J. Skerrett,Leonard D. Hudson,Thomas R. Martin +9 more
TL;DR: The molar ratios remained low for 7 d or longer, limiting the activity of soluble IL-1 beta and TNF-alpha in the lungs at the onset of ARDS.
Journal ArticleDOI
Amniotic fluid interleukin-6: A sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity
Bo Hyun Yoon,Roberto Romero,Chong Jai Kim,Jong Kwan Jun,Ricardo Gomez,Jung Hwan Choi,Hee Chul Syu +6 more
TL;DR: Amniotic fluid interleukin-6 is a sensitive test for the prospective diagnosis of acute histologic chorioamnionitis and the identification of neonates at risk for significant morbidity and mortality.
Journal ArticleDOI
Prevalence and Diversity of Microbes in the Amniotic Fluid, the Fetal Inflammatory Response, and Pregnancy Outcome in Women with Preterm Pre-Labor Rupture of Membranes
Daniel B. DiGiulio,Roberto Romero,Roberto Romero,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Ricardo Gomez,Chong Jai Kim,Chong Jai Kim,Kimberley S. Seok,Francesca Gotsch,Shali Mazaki-Tovi,Shali Mazaki-Tovi,Edi Vaisbuch,Edi Vaisbuch,Katherine Sanders,Katherine Sanders,Elisabeth M. Bik,Elisabeth M. Bik,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Oyarzún E,David A. Relman,David A. Relman +22 more
TL;DR: The prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre‐labor rupture of membranes are studied.
References
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Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.
Rachel Grossman,James G. Krueger,Debra Yourish,Angela Granelli-Piperno,Daniel P. Murphy,Lester T. May,Thomas S. Kupper,Pravinkumar B. Sehgal,Alice B. Gottlieb +8 more
TL;DR: Interleukin 6 could directly contribute to the epidermal hyperplasia seen in psoriatic epithelium as well as affect the function of dermal inflammatory cells.
Journal ArticleDOI
Infection and labor. III. Interleukin-1: a signal for the onset of parturition.
Roberto Romero,Dan T. Brody,E. Oyarzun,Moshe Mazor,Ying King Wu,John C. Hobbins,Scott K. Durum +6 more
TL;DR: The hypothesis that interleukin-1 may play a role in the initiation of preterm labor associated with intraamniotic infection is supported.
Journal ArticleDOI
Amniotic fluid interleukin 6 in preterm labor. Association with infection.
TL;DR: Evaluation of AF IL-6 levels may have diagnostic and prognostic value in the management of women in preterm labor and implicate IL- 6 in the host response to intrauterine infection.
Journal ArticleDOI
Apparent role of the macrophage growth factor, CSF-1, in placental development.
Jeffery W. Pollard,Jeffery W. Pollard,Anna Bartocci,Robert J. Arceci,Amos Orlofsky,M. B. Ladner,E. Richard Stanley +6 more
TL;DR: It is shown that uterine CSF-1 concentration is regulated by the synergistic action of female sex steroids, oestradiol-17β(E2) and progesterone (P) and that the elevation can be attributed to the preferential expression of an alternatively spliced CSf-1 mRNA by uterine glandular epithelial cells.