Journal ArticleDOI
Degenerative and axon outgrowth-altering effects of phencyclidine in human fetal cerebral cortical cells
TLDR
The present data suggest that high levels of PCP can disrupt the normal development of neural circuitry in the human fetus, which would be expected to result in profound functional impairments.About:
This article is published in Neuropharmacology.The article was published on 1992-03-01. It has received 20 citations till now. The article focuses on the topics: Phencyclidine & Neurite.read more
Citations
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Journal ArticleDOI
Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine.
Frank R. Sharp,M. Butman,M. Butman,S. Wang,S. Wang,J. Koistinaho,J. Koistinaho,Steven H. Graham,Steven H. Graham,Stephen M. Sagar,Stephen M. Sagar,Linda Noble,P. Berger,P. Berger,Frank M. Longo,Frank M. Longo +15 more
TL;DR: It is shown that PCP, MK801, and ketamine drug induced injury occurs in 30 day and older rats, but not in 0–20 day old rats, and is prevented by prior administration of the antipsychotic drugs haloperidol and rimcazole.
Journal ArticleDOI
Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels
Frank R. Sharp,M. Butman,Jari Koistinaho,K. Aardalen,R. Nakki,Steven M. Massa,Raymond A. Swanson,Stephen M. Sagar +7 more
TL;DR: The results suggest that phencyclidine injuries pyramidal neurons via dopamine D1, D2, D4, sigma and other receptors, and approaches for decreasing the clinical side effects of N-methyl-D-aspartate receptor antagonists to facilitate their possible use in the treatment of ischemia and other disorders.
Book ChapterDOI
Glial Modulators as Potential Treatments of Psychostimulant Abuse
TL;DR: This chapter discusses the molecular pharmacology, physiology, and functional relationships that the glia have especially in the light in which they present themselves as targets for pharmacotherapeutics intended to treat psychostimulant abuse disorders.
Journal ArticleDOI
DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex
TL;DR: DNQX inhibition of PCP/ketamine hsp70 induction was likely related to AMPA receptor antagonism which prevented excess calcium influx via voltage-gated calcium channels.
Journal ArticleDOI
NE-100, a novel sigma receptor ligand : effect on phencyclidine-induced behaviors in rats, dogs and monkeys
Shigeru Okuyama,Yasuko Imagawa,Takashi Sakagawa,Atsuro Nakazato,Kazumasa Yamaguchi,Masami Katoh,Shigeyuki Yamada,Hiroaki Araki,Susumu Otomo +8 more
TL;DR: It is indicated that NE-100 attenuates the effect of PCP in experimental animals, and this drug is being considered as a therapeutic for the treatment of patients in the schizophrenia.
References
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Journal ArticleDOI
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
Journal ArticleDOI
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
Amy B. MacDermott,Amy B. MacDermott,Mark L. Mayer,Gary L. Westbrook,Stephen J. Smith,Jeffery L. Barker +5 more
TL;DR: It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels.
Journal ArticleDOI
Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
TL;DR: These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.
Journal ArticleDOI
Calcium regulation of the neuronal growth cone.
TL;DR: Ca 2+ may act as a common integrator of environmental cues that influence neurite outgrowth and synaptogenesis, and in this way may play a key role in the establishment and modulation of brain circuitry.