Journal ArticleDOI
Degradation behaviour and mechanical properties of magnesium implants in rabbit tibiae
Annett Krause,Nina von der Höh,Dirk Bormann,Christian Krause,Friedrich-Willhelm Bach,H. Windhagen,Andrea Meyer-Lindenberg +6 more
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TLDR
Considering all results of WE43, its application as osteosynthesis material for fracture repair is ineligible due to its heterogeneous and unpredictable degradation behaviour and its use as degradable implant material seems to be limited.Abstract:
To investigate the initial mechanical strength and the degradation behaviour with the associated changes in mechanical properties of magnesium-based osteosynthesis implants, 30 rabbits were implanted with cylindrical pins of the alloys MgCa08 (magnesium with 08 wt% calcium), LAE442 (magnesium with 4 wt% lithium, 4 wt% aluminium and 2 wt% rare earths) and WE43 (magnesium with 4 wt% yttrium and 3 wt% rare earths) The implants were inserted into the medullary cavity of both tibiae After 3 and 6 months, each half of the animals was euthanized, respectively, and the implants were taken out A determination of volume, three-point bending tests, scanning electron microscopy (SEM) and energy dispersive X-ray analyses as well as metallographic and μ-computed tomography examinations were accomplished All implants were clinically well tolerated MgCa-implants showed the least initial strength and the highest loss in volume after 6 months SEM- and μ-computed tomography examinations revealed a pronounced pitting corrosion Therefore, their use as degradable implant material seems to be limited LAE442 has the best initial strength which seems to be sufficient for an application in weight-bearing bones The degradation behaviour is very constant However, possible unknown side effects of the rare earths have to be excluded in further investigations on biocompatibility Considering all results of WE43, its application as osteosynthesis material for fracture repair is ineligible due to its heterogeneous and unpredictable degradation behaviourread more
Citations
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Journal ArticleDOI
Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications
TL;DR: It was found that inclusion of alloying elements such as Al, Mn, Ca, Zn and rare earth elements provides improved corrosion resistance to Mg alloys and surface modification is a promising approach to improve the performance of Mg-based biomaterials for orthopaedic applications.
Journal ArticleDOI
Novel Magnesium Alloys Developed for Biomedical Application: A Review
Nan Li,Yufeng Zheng +1 more
TL;DR: A review of state-of-the-art of magnesium alloy implants and devices for orthopedic, cardiovascular and tissue engineering applications is presented in this article, where advances in new alloy design, novel structure design and surface modification are overviewed.
Journal ArticleDOI
Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone.
Tanja Kraus,Stefan Fischerauer,Anja C. Hänzi,Peter J. Uggowitzer,Jörg F. Löffler,Annelie Weinberg +5 more
TL;DR: Online μCT monitoring is shown to be suitable for evaluating materials degradation and bone response in vivo, providing continuous information on the implant and tissue performance in the same living animal.
Journal ArticleDOI
Comparison of the effects of Mg-6Zn and titanium on intestinal tract in vivo.
Jun Yan,Yigang Chen,Qingling Yuan,Song Yu,Wen-Cai Qiu,Cheng-Guang Yang,Zhigang Wang,Jianfeng Gong,Kaixing Ai,Qi Zheng,Jianan Li,Shaoxiang Zhang,Xiaonong Zhang +12 more
TL;DR: The study demonstrates that the Mg–6Zn alloy had good biocompatibility in vivo and performed better than titanium at promoting healing and reducing inflammation and may be a promising candidate for stapler pins in intestinal reconstruction.
Journal ArticleDOI
Comparison of the effects of Mg-6Zn and Ti-3Al-2.5V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tract in vivo.
Jun Yan,Yigang Chen,Qingling Yuan,Xiaohu Wang,Song Yu,Wen-Cai Qiu,Zhigang Wang,Kaixing Ai,Xiaonong Zhang,Shaoxiang Zhang,Changli Zhao,Qi Zheng +11 more
TL;DR: The Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation, and may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.
References
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Journal ArticleDOI
Titanium alloys in total joint replacement—a materials science perspective
Marc Long,H.J Rack +1 more
TL;DR: This review examines current information on the physical and mechanical characteristics of titanium alloys used in artifical joint replacement prostheses, with a special focus on those issues associated with the long-term prosthetic requirements, e.g., fatigue and wear.
Journal ArticleDOI
In vivo corrosion of four magnesium alloys and the associated bone response.
Frank Witte,Volker Kaese,Heinz Haferkamp,E. Switzer,Andrea Meyer-Lindenberg,Carl Joachim Wirth,H. Windhagen +6 more
TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.
Journal ArticleDOI
Corrosion mechanisms of magnesium alloys
Guang-Ling Song,Andrej Atrens +1 more
TL;DR: In this paper, a detailed review of the corrosion mechanisms of magnesium alloys is presented, and the basis for the design of new alloys with improved corrosion properties is provided for improving the corrosion properties.
Journal ArticleDOI
Understanding Magnesium Corrosion—A Framework for Improved Alloy Performance
Guang-Ling Song,Andrej Atrens +1 more
TL;DR: In this article, a mechanistic overview of the various types of magnesium corrosion is provided, and a theoretical framework for further, much needed research is provided. But, as stated in the introduction, "There is still vast scope both for better fundamental understanding of corrosion processes, engineering usage of magnesium, and also on the corrosion protection of magnesium alloys in service".