Dengue Epidemiology and Burden of Disease in Latin America and the Caribbean: A Systematic Review of the Literature and Meta-Analysis
Maria Luisa Cafferata,Ariel Bardach,Lucila Rey-Ares,Andrea Alcaraz,Gabriela Cormick,Luz Gibbons,Marina Romano,Silvana Cesaroni,Silvina Ruvinsky +8 more
TLDR
Activities to control dengue transmission in the region have been important but insufficient and the surveillance of d Dengue burden of disease and circulating strains help shape and evaluate the present and future health policies.Abstract:
Introduction: Dengue virus infection is the most common arthropodborne disease worldwide with approximately 50 to 100 million cases of dengue infection occurring annually. Globally, dengue incidence has increased in the last 40 years, especially in Latin American and Caribbean (LAC) countries where the highest incidence is found. This systematic review aimed to present information on dengue disease burden and use of health resources in the LAC region in the last 15 years. Methods: We searched the main international and regional databases and generic and academic Internet search engines. Gray literature was retrieved mainly from regional health ministries and Pan American Health Organization. A set of inclusion criteria was defined. Results: We identified 2,041 articles of which 25 met these criteria, 13 for incidence and 12 for the use of resources and related costs. The pooled incidence of classic dengue fever was 72.1 cases per 100,000 persons-years in the 44 LAC countries analyzed (95% confidence interval 71.5–72.7), with an upward trend from 1995 up to 2010. Case-fatality ratio was highest in 1997 (0.12 [0.05–0.22]) and lowest in 2009, and the overall mortality was 0.02 per 100,000 people. More than 60% of the cases in the LAC region came from Brazil. The length of hospital stay ranged from 5 to 13 days. Conclusions: Activities to control dengue transmission in the region have been important but insufficient. The surveillance of dengue burden of disease and circulating strains help shape and evaluate the present and future health policies.read more
Citations
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Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America
Luis Angel Villar,Gustavo H. Dayan,José Luis Arredondo-García,Doris Maribel Rivera,Rivaldo Venâncio da Cunha,Carmen Deseda,Humberto Reynales,Maria Selma N. Costa,Javier O Morales-Ramirez,Gabriel Carrasquilla,Luis Carlos Rey,Reynaldo Dietze,Kleber Giovanni Luz,Enrique Rivas,Maria Consuelo Miranda Montoya,Margarita Cortés Supelano,Betzana Zambrano,Edith Langevin,Mark Boaz,Nadia Tornieporth,Melanie Saville,Fernando Noriega +21 more
TL;DR: The CYD-TDV dengue vaccine was efficacious against V CD and severe VCD and led to fewer hospitalizations for VCD in five Latin American countries where d Dengue is endemic.
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The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study
Stefan Flasche,Mark Jit,Isabel Rodriguez-Barraquer,Laurent Coudeville,Mario Recker,Katia Koelle,George J. Milne,Thomas J. Hladish,T. Alex Perkins,Derek A. T. Cummings,Derek A. T. Cummings,Ilaria Dorigatti,Daniel J Laydon,Guido España,Joel Kelso,Ira M. Longini,José Lourenço,Carl A. B. Pearson,Robert C. Reiner,Luis Mier-y-Teran-Romero,Kirsten S. Vannice,Neil M. Ferguson +21 more
TL;DR: Predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9).
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Economic Impact of Dengue: Multicenter Study across Four Brazilian Regions
Celina Maria Turchi Martelli,João Bosco Siqueira,Mirian Perpetua Palha Dias Parente,Ana Laura de Sene Amancio Zara,C.S. Oliveira,Cynthia Braga,Fabiano Geraldo Pimenta,Fanny Cortes,Juan Guillermo Lopez,Luciana Bahia,Marcia Costa Ooteman Mendes,Michelle Quarti Machado da Rosa,Noemia Teixeira de Siqueira Filha,Dagna Constenla,Wayner Vieira de Souza +14 more
TL;DR: The economic burden associated with d Dengue in Brazil is substantial with large variations in reported cases and consequently costs reflecting the dynamic of dengue transmission.
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Epidemiological Scenario of Dengue in Brazil.
TL;DR: This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil.
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Why are people with dengue dying? A scoping review of determinants for dengue mortality
Mabel Carabali,Libia Milena Hernández,Maria Jose Arauz,Luis Angel Villar,Valéry Ridde,Valéry Ridde +5 more
TL;DR: Along with biological factors, social determinants of health (SDHs) are related to dengue deaths as well, and only a few have been systematically analyzed, suggesting the need for more studies on this subject to inform the design and implementation of sustainable interventions to decrease d Dengue mortality.
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