Journal ArticleDOI
Detection of breast cancer with ultrasound tomography: First results with the Computed Ultrasound Risk Evaluation (CURE) prototype
Nebojsa Duric,Peter Littrup,Lou Poulo,Alex Babkin,Roman Pevzner,Earle Holsapple,Olsi Rama,C Glide +7 more
Reads0
Chats0
TLDR
Initial results indicate that operator-independent, whole-breast imaging and the detection of breast masses are feasible, and future studies will focus on improved detection and differentiation of masses in support of the long-term goal of increasing the specificity of breast exams.Abstract:
Although mammography is the gold standard for breast imaging, its limitations result in a high rate of biopsies of benign lesions and a significant false negative rate for women with dense breasts. In response to this imaging performance gap we have been developing a clinical breast imaging methodology based on the principles of ultrasound tomography. The Computed Ultrasound Risk Evaluation (CURE) system has been designed with the clinical goals of whole breast, operator-independent imaging, and differentiation of breast masses. This paper describes the first clinical prototype, summarizes our initial image reconstruction techniques, and presents phantom and preliminary in vivo results. In an initial assessment of its in vivo performance, we have examined 50 women with the CURE prototype and obtained the following results. (1) Tomographic imaging of breast architecture is demonstrated in both CURE modes of reflection and transmission imaging. (2) In-plane spatial resolution of 0.5 mm in reflection and 4 mm in transmission is achieved. (3) Masses > 15 mm in size are routinely detected. (4) Reflection, sound speed, and attenuation imaging of breast masses are demonstrated. These initial results indicate that operator-independent, whole-breast imaging and the detection of breast masses are feasible. Future studies will focus on improved detection and differentiation of masses in support of our long-term goal of increasing the specificity of breast exams, thereby reducing the number of biopsies of benign masses.read more
Citations
More filters
Journal ArticleDOI
Euclidean Distance Matrices: Essential theory, algorithms, and applications
TL;DR: The fundamental properties of EDMs, such as rank or (non)definiteness, are reviewed, and it is shown how the various EDM properties can be used to design algorithms for completing and denoising distance data.
Journal ArticleDOI
In vivo breast sound-speed imaging with ultrasound tomography
TL;DR: Results suggest that, clinically, sound-speed tomograms can be used to assess breast density, as well as detect and help differentiate breast lesions, and may also be a useful tool to monitor the clinical response of breast cancer patients to neo-adjuvant chemotherapy.
Book
Acoustic Metamaterials: Negative Refraction, Imaging, Lensing and Cloaking
TL;DR: In this article, acoustic metamaterials have been used for low frequency surface acoustic band gap applications and transformation elastodynamics and active exterior acoustic cloaking with liquid surface waves and plasmonic shells.
BookDOI
Quantitative Ultrasound in Soft Tissues
Jonathan Mamou,Michael L. Oelze +1 more
TL;DR: This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.
Journal ArticleDOI
Breast cancer imaging: A perspective for the next decade
TL;DR: It appears that the primary imaging tool for breast cancer screening in the next decade will be high-resolution, high-contrast, anatomical x-ray imaging with or without depth information, and there is a trend towards multi-modality systems that combine anatomic with physiologic information.
References
More filters
Journal ArticleDOI
Effect of screening and adjuvant therapy on mortality from breast cancer
Donald A. Berry,Kathleen A. Cronin,Sylvia K. Plevritis,Dennis G. Fryback,Lauren Clarke,Marvin Zelen,Jeanne S. Mandelblatt,Andrei Yakovlev,J. Dik F. Habbema,Eric J. Feuer +9 more
TL;DR: Seven statistical models showed that both screening mammography and treatment have helped reduce the rate of death from breast cancer in the United States.
Journal ArticleDOI
Solid breast nodules: use of sonography to distinguish between benign and malignant lesions.
TL;DR: Sonography can be used to accurately classify some solid lesions as benign, allowing imaging follow-up rather than biopsy, and this distinction could be definite enough to obviate biopsy.
Journal ArticleDOI
Comparison of the Performance of Screening Mammography, Physical Examination, and Breast US and Evaluation of Factors that Influence Them: An Analysis of 27,825 Patient Evaluations
TL;DR: Mammographic sensitivity for breast cancer declines significantly with increasing breast density and is independently higher in older women with dense breasts, which significantly increases detection of small cancers and depicts significantly more cancers and at smaller size and lower stage than does PE, which detects independently extremely few cancers.
Journal ArticleDOI
Is screening for breast cancer with mammography justifiable
Peter C Gøtzsche,Ole Olsen +1 more
TL;DR: Screening for breast cancer with mammography is unjustified because for every 1000 women screened biennially throughout 12 years, one breast-cancer death is avoided whereas the total number of deaths is increased by six.
Journal ArticleDOI
Real-time spatial compound imaging : Application to breast, vascular, and musculoskeletal ultrasound
Robert R. Entrekin,Bruce A Porter,Henrik Sillesen,Anthony D Wong,Peter L. Cooperberg,Cathy H Fix +5 more
TL;DR: Future development of real-time spatial compound imaging will help address the bulk of general imaging applications by extending this technology to curved array transducers, tissue harmonics, panoramic imaging, and three-dimensional sonography.