Determining Chemotherapy Tolerance in Older Patients With Cancer
Jerome Kim,Arti Hurria +1 more
TLDR
The Comprehensive Geriatric Assessment pinpoints problems with daily activities, comorbidities, medications, nutritional status, cognitive function, psychological state, and social support systems, all of which are risk factors for treatment vulnerability in older adults with cancer.Abstract:
Older adults with cancer constitute a heterogeneous group of patients who pose unique challenges for oncology care. One major concern is how to identify patients who are at a higher risk for chemotherapy intolerance, because a standard oncology workup may not always be able to distinguish an older individual's level of risk for treatment-related complications. Geriatric oncologists incorporate tools used in the field of geriatrics, and have developed the Comprehensive Geriatric Assessment to enhance the standard oncology workup. This assessment pinpoints problems with daily activities, comorbidities, medications, nutritional status, cognitive function, psychological state, and social support systems, all of which are risk factors for treatment vulnerability in older adults with cancer. Additional tools that also serve to predict chemotherapy toxicity in older patients with cancer are now available to identify patients at higher risk for morbidity and mortality. Together, these instruments complement the standard oncology workup by providing a global assessment, thereby guiding therapeutic interventions that may improve a patient's quality of life and clinical outcomes.read more
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Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study
Xiao-Long Chen,Lian Xue,Wei Wang,Hai-Ning Chen,Wei-Han Zhang,Kai Liu,Xin-Zu Chen,Kun Yang,Bo Zhang,Zhi-Xin Chen,Jia-Ping Chen,Zong-Guang Zhou,Jiankun Hu +12 more
TL;DR: It is suggested that HALP was closely associated with clinicopathological features and was an independent prognostic factor in GC patients and Nomogram based on HALP could accurately predict the prognosis of GC patients.
Journal ArticleDOI
Emerging uses of patient generated health data in clinical research.
TL;DR: With successful integration, PGHD can catalyze the application of “big data” to cancer clinical research, creating both “n of 1” and population‐level observations, and generating new insights into the nature of health and disease.
Journal ArticleDOI
Comprehensive geriatric assessment in the older cancer patient: coming of age in clinical cancer care.
Cynthia Owusu,Nathan A. Berger +1 more
TL;DR: The current expansion of the geriatric population - their variable levels of fitness, frailty and vulnerability, the fact that cancer is primarily a disease of older adults, the significant expansion of agents and approaches to treat cancer, as well as their resultant toxicities and complications - has led to the development of specialized geriatric oncologists.
Journal ArticleDOI
Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer.
Nicolò Matteo Luca Battisti,Malcolm W.R. Reed,Esther Herbert,Jenna Morgan,Karen Collins,Sue Ward,Geoffrey Holmes,Mike Bradburn,Stephen J Walters,Maria Burton,Kate Lifford,Adrian Edwards,Thompson G. Robinson,Charlene Martin,Tim Chater,Kirsty Pemberton,Anne Shrestha,Alan Brennan,Kwok L. Cheung,Annaliza Todd,Riccardo A. Audisio,Juliet Wright,Richard Simcock,Tracey Green,Deirdre Revell,Jacqui Gath,Kieran Horgan,Chris Holcombe,Matthew C Winter,Jay Naik,Rishi Parmeshwar,Margot Gosney,Matthew Hatton,Alastair M. Thompson,Lynda Wyld,A. Ring,Age Gap Tmg +36 more
TL;DR: In this article, the negative impact of chemotherapy on quality of life is clinically and statistically significant at 6 months but resolves by 18 months, which is crucial to inform decision-making for older patients contemplating chemotherapy.
Journal ArticleDOI
Frailty status but not age predicts complications in elderly cancer patients: a follow-up study
TL;DR: Few elderly cancer patients seem to be fit and CGA predicts admittance to hospital in a population of elderly patients with mixed cancer diseases, and Frail and vulnerable patients have higher risk of death within 90 days as compared to fit patients.
References
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Journal ArticleDOI
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
Journal ArticleDOI
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal ArticleDOI
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.
Journal ArticleDOI
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
TL;DR: This study evaluated a modified, timed version of the “Get‐Up and Go” Test (Mathias et al, 1986) in 60 patients referred to a Geriatric Day Hospital and suggested that the timed “Up & Go’ test is a reliable and valid test for quantifying functional mobility that may also be useful in following clinical change over time.
Related Papers (3)
International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer
Hans Wildiers,Pieter Heeren,Martine Puts,Eva Topinkova,Maryska L.G. Janssen-Heijnen,Martine Extermann,Claire Falandry,Andrew S. Artz,Etienne Brain,Giuseppe Colloca,Johan Flamaing,Theodora Karnakis,Cindy Kenis,Riccardo A. Audisio,Supriya G. Mohile,Lazzaro Repetto,Barbara L. van Leeuwen,Koen Milisen,Arti Hurria +18 more