Development of Human Lateral Prefrontal Sulcal Morphology and Its Relation to Reasoning Performance
Reads0
Chats0
TLDR
In this paper , longitudinal changes in the cortex within specific lateral PFC sulci are behaviorally meaningful, providing targeted structures, and areas of the cortex, for future neuroimaging studies examining the development of cognitive abilities.Abstract:
Previous findings show that the morphology of folds (sulci) of the human cerebral cortex flatten during postnatal development. However, previous studies did not consider the relationship between sulcal morphology and cognitive development in individual participants. Here, we fill this gap in knowledge by leveraging cross-sectional morphologic neuroimaging data in the lateral PFC (LPFC) from individual human participants (6-36 years old, males and females; N = 108; 3672 sulci), as well as longitudinal morphologic and behavioral data from a subset of child and adolescent participants scanned at two time points (6-18 years old; N = 44; 2992 sulci). Manually defining thousands of sulci revealed that LPFC sulcal morphology (depth, surface area, and gray matter thickness) differed between children (6-11 years old)/adolescents (11-18 years old) and young adults (22-36 years old) cross-sectionally, but only cortical thickness showed differences across childhood and adolescence and presented longitudinal changes during childhood and adolescence. Furthermore, a data-driven approach relating morphology and cognition identified that longitudinal changes in cortical thickness of four left-hemisphere LPFC sulci predicted longitudinal changes in reasoning performance, a higher-level cognitive ability that relies on LPFC. Contrary to previous findings, these results suggest that sulci may flatten either after this time frame or over a longer longitudinal period of time than previously presented. Crucially, these results also suggest that longitudinal changes in the cortex within specific LPFC sulci are behaviorally meaningful, providing targeted structures, and areas of the cortex, for future neuroimaging studies examining the development of cognitive abilities.SIGNIFICANCE STATEMENT Recent work has shown that individual differences in neuroanatomical structures (indentations, or sulci) within the lateral PFC are behaviorally meaningful during childhood and adolescence. Here, we describe how specific lateral PFC sulci develop at the level of individual participants for the first time: from both cross-sectional and longitudinal perspectives. Further, we show, also for the first time, that the longitudinal morphologic changes in these structures are behaviorally relevant. These findings lay the foundation for a future avenue to precisely study the development of the cortex and highlight the importance of studying the development of sulci in other cortical expanses and charting how these changes relate to the cognitive abilities those areas support at the level of individual participants. read more
Citations
More filters
Journal ArticleDOI
Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees
TL;DR: In this paper , the surface anatomy of the human posteromedial cortex was compared between humans and non-human hominoids, and it was found that the prominent marginal ramus of the cingulate sulcus differs significantly between species.
Posted ContentDOI
Cognitive relevance of an evolutionarily new and variable prefrontal structure
Ethan H. Willbrand,Sam Jackson,Szeshuen Chen,Catherine B. Hathaway,Willa Voorhies,Silvia A. Bunge,Kevin S. Weiner +6 more
TL;DR: This paper found that the presence or absence of the paraintermediate frontal sulcus (pimfs-v) in lateral prefrontal cortex was related to relational reasoning in young adults from the Human Connectome Project.
Posted ContentDOI
Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees
Ethan H. Willbrand,Samira A. Maboudian,Joseph P. Kelly,Benjamin Jon Parker,Brett L. Foster,Kevin S. Weiner +5 more
TL;DR: For instance, this paper found that the surface anatomy of the human posteromedial cortex substantially differs between humans and chimpanzees, and that the prominent marginal ramus of the cingulate sulcus differs significantly between species.
Posted ContentDOI
Neuroanatomical and functional dissociations between variably present anterior lateral prefrontal sulci
TL;DR: For instance, this paper found that the dorsal and ventral components of the paraintermediate frontal sulcus (pimfs) of the lateral prefrontal cortex (LPFC) have distinct morphological, architectural, and functional properties.
Posted ContentDOI
Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease
TL;DR: In this paper , the authors manually defined 4,362 posteromedial cortex sulci in 432 hemispheres in 216 participants and found that a subset of these sulci were most associated with memory and executive function scores in older adults.
References
More filters
Journal ArticleDOI
Cortical surface-based analysis. I. Segmentation and surface reconstruction
TL;DR: A set of automated procedures for obtaining accurate reconstructions of the cortical surface are described, which have been applied to data from more than 100 subjects, requiring little or no manual intervention.
Journal ArticleDOI
Cortical Surface-Based Analysis II: Inflation, Flattening, and a Surface-Based Coordinate System
TL;DR: A set of procedures for modifying the representation of the cortical surface to inflate it so that activity buried inside sulci may be visualized, cut and flatten an entire hemisphere, and transform a hemisphere into a simple parameterizable surface such as a sphere for the purpose of establishing a surface-based coordinate system are designed.
Journal ArticleDOI
Measuring the thickness of the human cerebral cortex from magnetic resonance images
Bruce Fischl,Anders M. Dale +1 more
TL;DR: An automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy is presented.
Journal ArticleDOI
Dynamic mapping of human cortical development during childhood through early adulthood
Nitin Gogtay,Jay N. Giedd,Leslie Lusk,Kiralee M. Hayashi,Deanna Greenstein,A. Catherine Vaituzis,Tom F. Nugent,David H. Herman,Liv S. Clasen,Arthur W. Toga,Judith L. Rapoport,Paul M. Thompson +11 more
TL;DR: The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Journal ArticleDOI
The minimal preprocessing pipelines for the Human Connectome Project.
Matthew F. Glasser,Stamatios N. Sotiropoulos,J. Anthony Wilson,Timothy S. Coalson,Bruce Fischl,Jesper L. R. Andersson,Junqian Xu,Saâd Jbabdi,Matthew A. Webster,Jonathan R. Polimeni,David C. Van Essen,Mark Jenkinson +11 more
TL;DR: The minimal preprocessing pipelines for structural, functional, and diffusion MRI that were developed by the HCP to accomplish many low level tasks, including spatial artifact/distortion removal, surface generation, cross-modal registration, and alignment to standard space are described.
Related Papers (5)
Normative Brain Size Variation and the Remodeling of Brain Shape in Humans
Paul K. Reardon,Paul K. Reardon,Paul K. Reardon,Simon N. Vandekar,Siyuan Liu,Raihaan Patel,Raihaan Patel,Min Tae M. Park,Min Tae M. Park,Aaron Alexander-Bloch,Jakob Seidlitz,Jakob Seidlitz,Liv S. Clasen,Jonathan D. Blumenthal,Jay N. Giedd,Ruben C. Gur,Raquel E. Gur,Jason P. Lerch,M. Mallar Chakravarty,M. Mallar Chakravarty,Theodore D. Satterthwaite,Russell T. Shinohara,Armin Raznahan +22 more