Journal ArticleDOI
Diagnosis of megaloblastic anaemias.
Reads0
Chats0
TLDR
The wide use of serum B(12) and metabolite assays has resulted in the increasingly early diagnosis of B( Twelve) deficiency, often in patients without B( 12)-related symptoms (subclinical deficiency).About:
This article is published in Blood Reviews.The article was published on 2006-11-01. It has received 133 citations till now. The article focuses on the topics: Megaloblastic anemia & Methylmalonic acid.read more
Citations
More filters
Journal ArticleDOI
Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch,Christine M. Pfeiffer,Michael K. Georgieff,Gary M. Brittenham,Susan J. Fairweather-Tait,Richard F. Hurrell,Harry J. McArdle,Daniel J Raiten +7 more
TL;DR: A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
Journal ArticleDOI
An update on cobalamin deficiency in adults
TL;DR: Mutations in genes encoding endocytic receptors involved in the ileal absorption and cellular uptake of cobalamin have been recently uncovered and explain, at least in part, the hereditary component of megaloblastic anemia.
Journal ArticleDOI
Vitamin Deficiencies in Humans: Can Plant Science Help?
Thérésa Bridget Fitzpatrick,Gilles J. Basset,Patrick Borel,Patrick Borel,Patrick Borel,Fernando Carrari,Dean DellaPenna,Paul D. Fraser,Hanjo Hellmann,Sonia Osorio,Christophe Rothan,Christophe Rothan,Victoriano Valpuesta,Catherine Caris-Veyrat,Catherine Caris-Veyrat,Alisdair R. Fernie +15 more
TL;DR: While considerable advances have been made in understanding vitamin metabolic pathways in plants, more cross-disciplinary approaches must be adopted to provide adequate levels of all vitamins in the major staple crops to eradicate vitamin deficiencies from the global population.
Journal ArticleDOI
Advances in the understanding of cobalamin assimilation and metabolism
TL;DR: The synthesis of methylcobalamins and 5′‐deoxyadenosylcobalamin, their utilization in conjunction with methionine synthase and methylmalonylCoA mutase, respectively, and the metabolic consequences of defects in these pathways could provide insights into the clinical presentation of cobalamin deficiency.
Journal ArticleDOI
Nutrition in the age-related disablement process.
Marco Inzitari,Esmée L. Doets,Benedetta Bartali,Vassiliki Benetou,M. Di Bari,Marjolein Visser,Stefano Volpato,Giovanni Gambassi,Eva Topinkova,L. C. P. G. M. De Groot,Antoni Salvà +10 more
TL;DR: A critical review of different aspects related to the role of nutrition in the transition from independence to disability, and proposed future lines for research, including the determination of levels of inadequacy and target doses of supplements, the study of interactions (between nutrients within a diet and with other lifestyle aspects), and the association with functional outcomes.
References
More filters
Book ChapterDOI
de la Chapelle, A.
Peter Beighton,Greta Beighton +1 more
TL;DR: De la Chapelle dysplasia, also known as atelosteogenesis type II, is a lethal form of neonatal dwarfism in which gross limb shortening is associated with a characteristic triangular configuration of the radius and ulna.
Journal ArticleDOI
Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis
John Lindenbaum,E. B. Healton,D. G. Savage,J C Brust,T J Garrett,E R Podell,P D Marcell,Sally P. Stabler,Robert H. Allen +8 more
TL;DR: It is concluded that neuropsychiatric disorders due to cobalamin deficiency occur commonly in the absence of anemia or an elevated mean cell volume and that measurements of serum methylmalonic acid and total homocysteine both before and after treatment are useful in the diagnosis of these patients.
Journal ArticleDOI
Neurologic aspects of cobalamin deficiency.
TL;DR: A wide variety of neurologic symptoms and signs were encountered, however, including ataxia, loss of cutaneous sensation, muscle weakness, diminished or hyperactive reflexes, spasticity, urinary or fecal incontinence, orthostatic hypotension, Loss of vision, dementia, psychoses, and disturbances of mood.
Journal ArticleDOI
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies
TL;DR: It is concluded that normal levels of both methylmalonic acid and total homocysteine rule out clinically significant cobalamin deficiency with virtual certainty.