Journal ArticleDOI
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia.
Parham Taslimi,Hatice Esra Aslan,Yeliz Demir,Necla Öztaşkın,Ahmet Maraş,İlhami Gülçin,Şükrü Beydemir,Süleyman Göksu +7 more
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TLDR
In this study, aldose reductase was purified from purified from cow liver, and compounds were tested for their inhibition effects against of α-glycosidase enzyme and demonstrated efficient inhibition profiles with Ki values in the range of 14.44 ± 0.06 nM, and IC50 values inThe range of 11.72-46.61’nM.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-08-02. It has received 153 citations till now. The article focuses on the topics: Aldose reductase & Reductase.read more
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Antioxidants and antioxidant methods: an updated overview
TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
Journal ArticleDOI
Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors.
Serdar Burmaoglu,Serdar Burmaoglu,Ali Yilmaz,M. Fatih Polat,Ruya Kaya,İlhami Gülçin,Oztekin Algul +6 more
TL;DR: These derivatives' inhibitory potential on the tested enzymes are promising drug candidates for the treatment of diseases like glaucoma, leukemia, epilepsy; Alzheimer's disease; type-2 diabetes mellitus that are associated with high enzymatic activity of carbonic anhydrase, acetylcholine esterase, butyrylcholinesterases, and α-glycosidase.
Journal ArticleDOI
Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
TL;DR: This review summarizes the regulation of type 1 diabetes mellitus by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue.
Journal ArticleDOI
Novel 2-aminopyridine liganded Pd(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties
Fatoş Erdemir,Duygu Barut Celepci,Aydın Aktaş,Yetkin Gök,Ruya Kaya,Parham Taslimi,Yeliz Demir,İlhami Gülçin +7 more
TL;DR: The synthesis, crystal structure, characterization, and enzyme inhibition effects of the novel a series of 2-aminopyridine liganded Pd(II) N-heterocyclic carbene (NHC) complexes were examined and the inhibition effect of these derivatives on aldose reductase and α-glycosidase enzymes was studied.
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Anticholinergic and antioxidant activities of usnic acid-an activity-structure insight.
Kader Cetin Cakmak,İlhami Gülçin +1 more
TL;DR: The results clearly showed that usnic acid is an important natural product with antioxidant and anticholinergic potentials and showed the potent inhibition profiles against AChE and BChE enzymes.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
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Radical scavenging and antioxidant activity of tannic acid
TL;DR: In this article, the authors examined the in vitro radical scavenging and antioxidant capacity of tannic acid by using different in vitro analytical methodologies such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH ) scavenging, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) activity, total antioxidant activity determination by ferric thiocyanate, total reducing ability determination using by Fe3+−Fe2+ transformation