Journal ArticleDOI
Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals.
Juan-R. Malagelada,Juan-R. Malagelada,Vay Liang W. Go,Vay Liang W. Go,William H.J. Summerskill,William H.J. Summerskill +5 more
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TLDR
It is suggested that gastric, pancreatic, and biliary responses to liquid test meals introduced into the stomach may differ substantially from the presumably more physiological response to ordinary solid-liquid meals.Abstract:
We have compared responses to an ordinary solid-liquid (S) meal and to a homogenized (H) meal of identical composition (sirloin steak, bread, butter, ice cream with chocolate syrup, and water) by measuring simultaneously postprandial gastric, pancreatic, and biliary functions by marker-perfusion techniques Responses to each (S or H) meals differed strikingly both in magnitude and pattern S meals elicited a stronger early gastric secretory response (acid, pepsin, and volume) which compensated for faster initial emptying and resulted in higher gastric acidity and volume than after H meals Further, nutrients ingested with S meals were emptied at a slower rate than H (as evidenced by a more gradual decline in intragastric buffer and osmolality, as well as time required for complete emptying of the meal) This, in turn, prolonged pancreatic and biliary responses since stimulation of these organs continued for as long as meal was delivered into the duodenum However, early biliary outputs (gallbladder response) were less after S than H, probably because nutrients entered the duodenum more slowly and were initially diluted by rapidly emptying water The physical characteristics of each meal (encompassing appearance, taste, and form of ingestion) probably accounted for early differences in digestive responses Later, interactions between gastric (motor and secretory), pancreatic, and biliary functions played a major role Our findings suggest that gastric, pancreatic, and biliary responses to liquid test meals introduced into the stomach may differ substantially from the presumably more physiological response to ordinary solid-liquid mealsread more
Citations
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Journal ArticleDOI
A standardised static in vitro digestion method suitable for food – an international consensus
Mans Minekus,Marie Alminger,Paula Alvito,Simon Ballance,Torsten Bohn,Claire Bourlieu,Claire Bourlieu,Frédéric Carrière,Rachel Boutrou,Rachel Boutrou,Milena Corredig,Didier Dupont,Didier Dupont,Claire Dufour,Lotti Egger,Matt Golding,Sibel Karakaya,Bente Kirkhus,S. Le Feunteun,Uri Lesmes,Adam Macierzanka,Alan R. Mackie,Sébastien Marze,David Julian McClements,Olivia Ménard,Olivia Ménard,Isidra Recio,Cláudia N. Santos,Rajat Singh,Gerd E. Vegarud,Martin S. J. Wickham,Werner Weitschies,André Brodkorb +32 more
TL;DR: In this article, the authors proposed a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements.
A standardised static in vitro digestion method suitable for food – an international consensus
Mans Minekus,Marie Alminger,Paula Alvito,Simon Ballance,Torsten Bohn,Claire Bourlieu,Claire Bourlieu,Frédéric Carrière,Rachel Boutrou,Rachel Boutrou,Milena Corredig,Didier Dupont,Didier Dupont,Claire Dufour,Lotti Egger,Matt Golding,Sibel Karakaya,Bente Kirkhus,S. Le Feunteun,Uri Lesmes,Adam Macierzanka,Alan R. Mackie,Sébastien Marze,David Julian McClements,Olivia Ménard,Olivia Ménard,Isidra Recio,Cláudia N. Santos,Rajat Singh,Gerd E. Vegarud,Martin S. J. Wickham,Werner Weitschies,André Brodkorb +32 more
TL;DR: A general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements, is proposed.
Journal ArticleDOI
Human pancreatic exocrine response to nutrients in health and disease.
TL;DR: A comprehensive knowledge about the physiological pancreatic exocrine response to normal diets and to individual food components is necessary to administer a pancreatic enzyme preparation which imitates physiological conditions closely.
Journal ArticleDOI
Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans.
TL;DR: Globally during the whole digestion period, gastric lipase might hydrolyze 1 acyl chain of 4, which need to be hydrolyzed for a complete intestinal absorption of monoglycerides and free fatty acids resulting from the degradation of two triglyceride molecules.
References
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Gastric Acid Secretion Rate and Buffer Content of the Stomach after Eating. RESULTS IN NORMAL SUBJECTS AND IN PATIENTS WITH DUODENAL ULCER
John S. Fordtran,John H. Walsh +1 more
TL;DR: It was shown that the rate of acid secretion in response to a steak meal in seven duodenal ulcer patients was twice the rate achieved in six control subjects and that the amount of acid secreted after eating exceeded the peak histamine response in the ulcers but not in the controls.
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pH dependence of acid secretion and gastrin release in normal and ulcer subjects.
TL;DR: A defect in autoregulation of gastrin release and gastric acid secretion at low pH in ulcer patients is suggested which may play a role in pathogenesis of this disease.
Journal ArticleDOI
Measurement of gastric functions during digestion of ordinary solid meals in man.
TL;DR: Using this method, acid, pepsin, and total secretory outputs; rates of gastric emptying of meal and secretions; and serum gastrin levels during digestion characterize physiological responses to ordinary food in health.
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A standardised static in vitro digestion method suitable for food – an international consensus
Mans Minekus,Marie Alminger,Paula Alvito,Simon Ballance,Torsten Bohn,Claire Bourlieu,Claire Bourlieu,Frédéric Carrière,Rachel Boutrou,Rachel Boutrou,Milena Corredig,Didier Dupont,Didier Dupont,Claire Dufour,Lotti Egger,Matt Golding,Sibel Karakaya,Bente Kirkhus,S. Le Feunteun,Uri Lesmes,Adam Macierzanka,Alan R. Mackie,Sébastien Marze,David Julian McClements,Olivia Ménard,Olivia Ménard,Isidra Recio,Cláudia N. Santos,Rajat Singh,Gerd E. Vegarud,Martin S. J. Wickham,Werner Weitschies,André Brodkorb +32 more