Journal ArticleDOI
Diffuse lung disease in infancy and childhood: expanding the chILD classification.
TLDR
The aims of this study were to determine the utility and reproducibility of this classification system for DPLD in children <2 years of age, and test its extension to 18 years ofAge.Abstract:
Aims
Diffuse parenchymal lung diseases (DPLD) in children comprise a wide spectrum of rare disorders. In 2007 the Children's Interstitial Lung Disease (chILD) Research Cooperative proposed a classification system for DPLD in children <2 years of age. The aims of our study were to determine the utility and reproducibility of this system in children <2 years of age, and test its extension to 18 years of age.
Methods and results
Of 211 cases, 93 were <2 years of age at presentation and 58% were included in the chILD classification. In 118 cases aged between 2 and 18 years there was a wider distribution of disorders, overlapping with those seen in adults, necessitating expansion of the chILD classification types to encompass all reviewed cases, in particular patients with ‘adult’ diffuse lung diseases. Many cases showed mixed histological patterns, overlap often being between groups of disorders more prevalent in infancy. Concordance between reporting pathologists was 90%.
Conclusions
The chILD scheme allows classification of conditions more common in children <2 years of age. It can be applied to children of any age, although additional entities need to be included. We propose a more histologically based system for use when assessing biopsies in this context.read more
Citations
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Journal ArticleDOI
European protocols for the diagnosis and initial treatment of interstitial lung disease in children
Andrew Bush,Steve Cunningham,Jacques de Blic,Angelo Barbato,Annick Clement,Ralph Epaud,Meike Hengst,Nural Kiper,Andrew G. Nicholson,Martin Wetzke,Deborah Snijders,Nicolaus Schwerk,Matthias Griese +12 more
TL;DR: Proposals for a staged investigation of chILD, starting from when the condition is suspected to defining the diagnosis, using pathways dependent on the clinical condition and the degree of illness of the child are reported.
Journal ArticleDOI
Interstitial Lung Disease in Newborns
TL;DR: The underlying mechanisms, clinical, imaging, and lung pathology features and outcomes of ILD presenting in newborns are reviewed with an emphasis on genetic mechanisms and diagnosis.
Journal ArticleDOI
Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme.
Leland L. Fan,Megan K. Dishop,Csaba Galambos,Frederic B. Askin,Frances V. White,Claire Langston,Deborah R. Liptzin,Miranda E. Kroehl,Gail H. Deutsch,Lisa R. Young,Geoffrey Kurland,James S. Hagood,Sharon D. Dell,Bruce C. Trapnell,Robin R. Deterding +14 more
TL;DR: In patients 2 to 18 years of age who underwent lung biopsies for diffuse lung disease, there were far fewer diagnoses prevalent in infancy and more overlap with adult diagnoses and Pulmonary hypertension was found to be a risk factor for mortality but only in the immunocompetent patients.
Journal ArticleDOI
Sex and the lung: Observations, hypotheses, and future directions
TL;DR: Sex‐related differences in a variety of lung diseases in infants and young children are reviewed, including respiratory distress syndrome, and chronic lung disease of prematurity, lower respiratory tract illnesses and wheezing, asthma, diffuse, and interstitial lung diseases, and cystic fibrosis.
Journal ArticleDOI
Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis
Jenna Hildebrandt,Ebru Yalcin,Hans-Georg Bresser,Güzin Cinel,Monika Gappa,Alireza Haghighi,Nural Kiper,Soheila Khalilzadeh,Karl Reiter,John A. Sayer,Nicolaus Schwerk,Anke Sibbersen,Sabine Van daele,Georg Nübling,Peter Lohse,Matthias Griese +15 more
TL;DR: This cohort broadens the spectrum of knowledge about the clinical variability and genotype-phenotype correlations of juvenile PAP, and illustrates the favorable outcome of WLL treatment in severely affected patients.
References
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Journal ArticleDOI
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Journal ArticleDOI
ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias.
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Journal ArticleDOI
Diffuse lung disease in young children: application of a novel classification scheme.
Gail H. Deutsch,Lisa R. Young,Robin R. Deterding,Leland L. Fan,Sharon D. Dell,Judy A. Bean,Alan S. Brody,Lawrence M. Nogee,Bruce C. Trapnell,Claire Langston,Eric A. Albright,Frederic B. Askin,Peter B. Baker,Pauline M. Chou,Carlyne M. Cool,Susan Coventry,Ernest Cutz,Mary M. Davis,Megan K. Dishop,Csaba Galambos,Kathleen Patterson,William D. Travis,Susan E. Wert,Frances V. White +23 more
TL;DR: This retrospective cohort study identifies a diverse spectrum of lung disorders, largely unique to young children, that will enhance accurate description and diagnosis of these disorders.
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