Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization
Patrick H. Finan,Luis F. Buenaver,S. Bounds,Shahid Hussain,R. Park,Uzma Haque,Claudia M. Campbell,Jennifer A. Haythornthwaite,Robert R. Edwards,Michael T. Smith +9 more
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TLDR
The results suggest that central sensitization in knee OA is especially apparent among patients with reports of high levels of clinical pain in the absence of moderate-to-severe radiographic evidence of pathologic changes of knee Oa.Abstract:
Objective
Radiographic measures of the pathologic changes of knee osteoarthritis (OA) have shown modest associations with clinical pain. We sought to evaluate possible differences in quantitative sensory testing (QST) results and psychosocial distress profiles between knee OA patients with discordant versus congruent clinical pain reports relative to radiographic severity measures.read more
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Assessment and manifestation of central sensitisation across different chronic pain conditions.
Lars Arendt-Nielsen,Bart Morlion,Serge Perrot,Albert Dahan,Anthony H. Dickenson,Hans G. Kress,Chris Wells,Didier Bouhassira,A. Mohr Drewes +8 more
TL;DR: Some common fundamental central pain mechanisms are introduced and how they may translate into the clinical signs and symptoms across different chronic pain conditions, how to evaluate gain and loss of function using quantitative pain assessment tools, and the implications for optimising prevention and management of pain are discussed.
Journal ArticleDOI
An overview of animal models of pain: disease models and outcome measures.
Nicholas S. Gregory,Amber L. Harris,Caleb R. Robinson,Patrick M. Dougherty,Perry N. Fuchs,Kathleen A. Sluka +5 more
TL;DR: The common methods used for inducing each of the pain phenotypes related to clinical pain syndromes as well as the main behavioral tests for assessing pain in each model are discussed.
Journal ArticleDOI
Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review.
TL;DR: Overall results suggest that, although peripheral mechanisms are involved in OA pain, hypersensitivity of the CNS plays a significant role in a subgroup of subjects within this population of patients.
Journal ArticleDOI
Towards a mechanism-based approach to pain management in osteoarthritis
TL;DR: It is expected that increased understanding of the mechanisms by which chronic OA-associated pain is generated and maintained will offer opportunities for targeting and improving the safety of analgesia, and it might become possible to identify subsets of patients with pain of different pathophysiology, thus enabling a tailored approach to pain management.
Journal ArticleDOI
Can quantitative sensory testing move us closer to mechanism-based pain management?
TL;DR: Although evidence suggests that QST may be useful in a mechanism-based classification of pain, there are gaps in current understanding that need to be addressed including making QST more applicable in clinical settings.
References
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TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
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The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research.
TL;DR: The clinimetric and clinical properties of the PSQI suggest its utility both in psychiatric clinical practice and research activities.
Journal ArticleDOI
Radiological Assessment of Osteo-Arthrosis
J. H. Kellgren,J. S. Lawrence +1 more
TL;DR: It was concluded that, to ensure maximum uniformity in grading x rays in field surveys and therapeutic trials, all readings should be made by the same observer, preferably at a single session.
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