Doença de Alzheimer
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TLDR
This paper concisely reviews the genetics of Alzheimer Disease and ribosomal gene alterations are discussed as possible mechanisms underlying genetic progeroid syndromes such as AD.About:
This article is published in Revista Brasileira de Psiquiatria.The article was published on 1999-10-01 and is currently open access. It has received 113 citations till now. The article focuses on the topics: Presenilin & Alzheimer's disease.read more
Citations
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Diagnóstico diferencial das demências
TL;DR: The correct and early diagnosis of primary degenerative dementia carries therapeutic and prognostic implications, which may attenuate the inevitable cognitive and behavioral deficits.
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A transição de saúde e as mudanças na expectativa de vida saudável da população idosa: possíveis impactos da prevenção de doenças crônicas
TL;DR: A classificacao das doencas cronicas, segundo o impacto na expectativa de vida livre de incapacidade, podera auxiliar no planejamento de programas de prevencao e promocao da saude.
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O impacto da doença de Alzheimer no cuidador
TL;DR: Current revision study shows the main determinant aspects on the impact on care nurses with Alzheimer Disease, as well as the main factors associated with the patient's institutionalization.
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Oral health of the elderly with Alzheimer's disease.
Giselle Rodrigues Ribeiro,José Luiz Riani Costa,Gláucia Maria Bovi Ambrosano,Renata Cunha Matheus Rodrigues Garcia +3 more
TL;DR: Elderly subjects with AD had poorer oral health than those without the disease and tended to decline as their disease progressed, despite the positive self-perception of their oral health.
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Theories of Aging and the Prevalence of Alzheimer's Disease.
Kaynara Trevisan,Renata Cristina-Pereira,Danyelle Silva-Amaral,Tales Alexandre Aversi-Ferreira,Tales Alexandre Aversi-Ferreira +4 more
TL;DR: The general idea is that AD is associated with aging in such a way that almost all people will present this disease; however, it is plausible to consider that the increase in life expectancy will generate a high prevalence of AD.
References
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Candidate gene for the chromosome 1 familial Alzheimer's disease locus
Ephrat Levy-Lahad,Wilma Wasco,Parvoneh Poorkaj,Donna M. Romano,Junko Oshima,Warren H. Pettingell,Chang En Yu,P. D. Jondro,Stephen D. Schmidt,Kai Wang,Annette C. Crowley,Ying-Hui Fu,Suzanne Y. Guénette,David J. Galas,Ellen Nemens,Ellen M. Wijsman,Thomas D. Bird,Gerard D. Schellenberg,Rudolph E. Tanzi +18 more
TL;DR: The presence of missense mutations in AD subjects in two highly similar genes strongly supports the hypothesis that mutations in both are pathogenic.
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Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
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The genetic defect causing familial Alzheimer's disease maps on chromosome 21
Peter St George-Hyslop,Rudolph E. Tanzi,Ronald J. Polinsky,Jonathan Haines,Linda Nee,Paul C. Watkins,Richard H. Myers,Richard H. Myers,Robert G. Feldman,Daniel A. Pollen,David A. Drachman,John H. Growdon,Amalia C. Bruni,Jean-François Foncin,Denise Salmon,P. Frommelt,Luigi Amaducci,Sandro Sorbi,Silva Piacentini,Gordon Stewart,Wendy Hobbs,P. Michael Conneally,James F. Gusella +22 more
TL;DR: The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21 and provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome.
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Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14.
Gerard D. Schellenberg,Thomas D. Bird,Ellen M. Wijsman,Harry T. Orr,Leojean Anderson,Ellen Nemens,June A. White,Lori L.C. Bonnycastle,James L. Weber,M. Elisa Alonso,Huntington Potter,Leonard L. Heston,George M. Martin +12 more
TL;DR: Evidence indicates a familial Alzheimer's disease locus on chromosome 14, which is found in early-onset non-Volga German kindreds, and results for the Volga German families were either negative or nonsignificant for markers in this region.
Journal Article
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
Margaret A. Pericak-Vance,J. L. Bebout,P. C. Gaskell,Larry H. Yamaoka,W. Y. Hung,Mark J. Alberts,A. P. Walker,Richard J. Bartlett,C. A. Haynes,Kathleen A. Welsh,N. L. Earl,Albert Heyman,C. M. Clark,A. D. Roses +13 more
TL;DR: Application of standard likelihood (LOD score) analysis to these data support the possibility of an FAD gene locate on CH19, particularly in the late-onset FAD families, and delineate this region of CH19 as an area needing additional investigation in FAD.