Journal ArticleDOI
Dopamine neuron systems in the brain: an update.
TLDR
The purpose of the present review is to summarize the current knowledge of the diversity and neurochemical features of the nine dopamine-containing neuronal cell groups in the mammalian brain, their distinctive cellular properties, and their ability to regulate their dopaminergic transmitter machinery in response to altered functional demands and aging.About:
This article is published in Trends in Neurosciences.The article was published on 2007-05-01. It has received 1551 citations till now. The article focuses on the topics: Dopaminergic & Neurochemical.read more
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Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Dopamine in Motivational Control: Rewarding, Aversive, and Alerting
TL;DR: It is proposed that dopamine neurons come in multiple types that are connected with distinct brain networks and have distinct roles in motivational control, and it is hypothesized that these dopaminergic pathways for value, salience, and alerting cooperate to support adaptive behavior.
Journal ArticleDOI
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Hsing-Chen Tsai,Feng Zhang,Antoine Roger Adamantidis,Garret D. Stuber,Antonello Bonci,Luis de Lecea,Karl Deisseroth +6 more
TL;DR: In this article, the authors used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals and found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking.
Supporting Online Material for Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Hsing-Chen Tsai,Feng Zhang,Antoine Roger Adamantidis,Garret D. Stuber,Antonello Bonci,Luis de Lecea,Karl Deisseroth +6 more
TL;DR: It is found that phasic activation of dopaminergic neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking.
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Input-specific control of reward and aversion in the ventral tegmental area
Stephan Lammel,Byung Kook Lim,Chen Ran,Kee Wui Huang,Michael J. Betley,Kay M. Tye,Karl Deisseroth,Robert C. Malenka +7 more
TL;DR: It is established that distinct VTA circuits generate reward and aversion, and thereby provides a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours.
References
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Journal ArticleDOI
Genome-wide atlas of gene expression in the adult mouse brain
Ed S. Lein,Michael Hawrylycz,Nancy Ao,Mikael Ayres,Amy Bensinger,Amy Bernard,Andrew F. Boe,Mark S. Boguski,Mark S. Boguski,Kevin S. Brockway,Emi J. Byrnes,Lin Chen,Li Chen,Tsuey-Ming Chen,Mei Chi Chin,Jimmy Chong,Brian E. Crook,Aneta Czaplinska,Chinh Dang,Suvro Datta,Nick Dee,Aimee L. Desaki,Tsega Desta,Ellen Diep,Tim A. Dolbeare,Matthew J. Donelan,Hong-Wei Dong,Jennifer G. Dougherty,Ben J. Duncan,Amanda Ebbert,Gregor Eichele,Lili K. Estin,Casey Faber,Benjamin A.C. Facer,Rick Fields,Shanna R. Fischer,Tim P. Fliss,Cliff Frensley,Sabrina N. Gates,Katie J. Glattfelder,Kevin R. Halverson,Matthew R. Hart,John G. Hohmann,Maureen P. Howell,Darren P. Jeung,Rebecca A. Johnson,Patrick T. Karr,Reena Kawal,Jolene Kidney,Rachel H. Knapik,Chihchau L. Kuan,James H. Lake,Annabel R. Laramee,Kirk D. Larsen,Christopher Lau,Tracy Lemon,Agnes J. Liang,Ying Liu,Lon T. Luong,Jesse Michaels,Judith J. Morgan,Rebecca J. Morgan,Marty Mortrud,Nerick Mosqueda,Lydia Ng,Randy Ng,Geralyn J. Orta,Caroline C. Overly,Tu H. Pak,Sheana Parry,Sayan Dev Pathak,Owen C. Pearson,Ralph B. Puchalski,Zackery L. Riley,Hannah R. Rockett,Stephen A. Rowland,Joshua J. Royall,Marcos J. Ruiz,Nadia R. Sarno,Katherine Schaffnit,Nadiya V. Shapovalova,Taz Sivisay,Clifford R. Slaughterbeck,Simon Smith,Kimberly A. Smith,Bryan I. Smith,Andy J. Sodt,Nick N. Stewart,Kenda-Ruth Stumpf,Susan M. Sunkin,Madhavi Sutram,Angelene Tam,Carey D. Teemer,Christina Thaller,Carol L. Thompson,Lee R. Varnam,Axel Visel,Axel Visel,Ray M. Whitlock,Paul Wohnoutka,Crissa K. Wolkey,Victoria Y. Wong,Matthew J.A. Wood,Murat B. Yaylaoglu,Rob Young,Brian L. Youngstrom,Xu Feng Yuan,Bin Zhang,Theresa A. Zwingman,Allan R. Jones +109 more
TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal Article
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
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Book reviewHandbook of Chemical Neuroanatomy: Methods in Chemical Neuroanatomy. Edited by A. Bjorklund and T. Hokfelt. Elsevier, Amsterdam, 1983. Cloth bound, 548 pp. UK £140. (Volume 1 in the series).
Journal ArticleDOI
Fluorescence of Catechol Amines and Related Compounds Condensed With Formaldehyde
TL;DR: In this article, the reaction between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied under mild conditions and it has been shown that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble.