Journal ArticleDOI
Dopamine receptors and brain function.
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TLDR
The recent characterization of D3 and D4 receptors which are, interestingly, expressed in areas of the CNS mediating cognition and affect or showing increased affinity for certain neuroleptics, have renewed the interest and hope of finding effective neurolePTics devoid of side effects.About:
This article is published in Neuropharmacology.The article was published on 1996-01-01. It has received 565 citations till now. The article focuses on the topics: D1-like receptor & D2-like receptor.read more
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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
TL;DR: Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).
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Molecular Imaging with PET
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Dopamine as a prolactin (PRL) inhibitor.
Nira Ben-Jonathan,Robert Hnasko +1 more
TL;DR: PRL homeostasis should be viewed in the context of a fine balance between the action of dopamine as an inhibitor and the many hypothalamic, systemic, and local factors acting as stimulators, none of which has yet emerged as a primary PRL releasing factor.
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Dopamine-mediated regulation of corticostriatal synaptic plasticity
TL;DR: A model in which the spontaneous membrane oscillations of neurons projecting from the striatum, in addition to the pattern of release of endogenous dopamine, bias the synapse towards preferential induction of LTP or LTD is proposed.
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Ruthenium-catalyzed N-alkylation of amines and sulfonamides using borrowing hydrogen methodology.
M. Haniti S. A. Hamid,C. Liana Allen,Gareth W. Lamb,Aoife C. Maxwell,Hannah C. Maytum,Andrew Watson,Jonathan M. J. Williams +6 more
TL;DR: The alkylation of amines by alcohols has been achieved using 0.5 mol % [Ru(p-cymene)Cl(2)](2) with the bidentate phosphines dppf or DPEphos as the catalyst.
References
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Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
Charles R. Gerfen,Thomas M. Engber,Lawrence C. Mahan,Zvi Susel,Thomas N. Chase,Frederick J. Monsma,David R. Sibley +6 more
TL;DR: The differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
TL;DR: The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease.
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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
TL;DR: In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TL;DR: Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.