Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer.
Chia-Chun Chao,Chia-Chun Chao,Po-Han Wu,Hsiang-Chi Huang,Hsiang-Chi Huang,Hsiao-Yu Chung,Yu Chi Chou,Bi-He Cai,Bi-He Cai,Reiji Kannagi,Reiji Kannagi +10 more
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TLDR
It is proposed that miR‐199a/b‐5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT and that it binds directly to theGCNT2 3′ untranslated region intracellularly in RNA‐induced silencing complex‐trap assays.About:
This article is published in FEBS Letters.The article was published on 2017-07-01 and is currently open access. It has received 31 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Epidermal growth factor.read more
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The epigenetics of epithelial-mesenchymal plasticity in cancer
Wai Leong Tam,Robert A. Weinberg +1 more
TL;DR: In this article, a review of the interactions between EMT-inducing transcription factors and epigenetic modulators during cancer progression and the therapeutic implications of exploiting this intricate regulatory process is presented.
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Adaptive boosting-based computational model for predicting potential miRNA-disease associations.
Yan Zhao,Xing Chen,Jun Yin +2 more
TL;DR: Adaptive Boosting for MiRNA-Disease Association prediction (ABMDA) is developed to predict potential associations between diseases and miRNAs and was able to improve the accuracy of given learning algorithm by integrating weak classifiers that could score samples to form a strong classifier based on corresponding weights.
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Long non-coding RNA ANRIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer.
Xu Shuangta,Xu Jianhua,Zheng Zhengrong,Zhao Qingquan,Zeng Xiaoshan,Cheng Sixian,Yinghui Liang,Qing-Fu Hu +7 more
TL;DR: It is demonstrated that ANRIL overexpression modulated TNBC tumorigenesis through acting as molecular 'sponge' for miR-199a, providing a novel insight and therapeutic target for TNBC.
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Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery.
TL;DR: It is demonstrated that LECs produce proinflammatory cytokines immediately following lens injury that could drive postsurgical flare, and suggested that inflammation may be a major player in the onset of lens-associated fibrotic disease PCS.
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A Systematic Review on the Implications of O-linked Glycan Branching and Truncating Enzymes on Cancer Progression and Metastasis
Rohitesh Gupta,Frank Leon,Sanchita Rauth,Surinder K. Batra,Surinder K. Batra,Moorthy P. Ponnusamy,Moorthy P. Ponnusamy +6 more
TL;DR: A comprehensive review of several initiating enzymes involved in the synthesis of O-linked glycosylation that significantly contribute to a number of different cancers.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.