Dynamics of respiratory and cardiac CSF motion revealed with real-time simultaneous multi-slice EPI velocity phase contrast imaging.
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TLDR
An extremely fast, real-time, and quantitative MRI technique to image CSF velocity in simultaneous multi-slice (SMS) echo planar imaging (EPI) acquisitions of 3 or 6 slice levels simultaneously over 30s and observe 3D spatial distributions ofCSF velocity is developed.About:
This article is published in NeuroImage.The article was published on 2015-11-15 and is currently open access. It has received 89 citations till now. The article focuses on the topics: Cardiac cycle.read more
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Book ChapterDOI
The blood-brain barrier.
TL;DR: This chapter focuses on the specialized multicellular structure and function of the BBB/neurovascular unit and discusses how BBB breakdown can precede or be a consequence of neuroinflammation, and explores new therapeutic avenues to repair a damaged BBB.
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Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System.
Steffi Dreha-Kulaczewski,Arun A. Joseph,Klaus-Dietmar Merboldt,Hans-Christoph Ludwig,Jutta Gärtner,Jens Frahm +5 more
TL;DR: The finding of a human CSF–venous network with upward CSF net movement opens new clinical concepts for drug delivery and new classifications and therapeutic options for various forms of hydrocephalus and ideopathic intracranial hypertension.
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Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
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Fluid Transport in the Brain.
TL;DR: In this paper, the authors describe the glymphatic system of the brain, which meets the brain's requisites to maintain homeostasis similar to peripheral organs, considering the blood-brain-barrier and the paths for formation and egress of the CSF.
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Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real‐time phase‐contrast MRI
Selda Yildiz,Suraj Thyagaraj,Ning Jin,Xiaodong Zhong,Xiaodong Zhong,Soroush Heidari Pahlavian,Bryn A. Martin,Francis Loth,John N. Oshinski,Karim G. Sabra +9 more
TL;DR: To validate a real‐time phase contrast magnetic resonance imaging sequence in a controlled phantom model, and to quantify the relative contributions of respiration and cardiac pulsations on cerebrospinal fluid velocity at the level of the foramen magnum (FM).
References
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Journal ArticleDOI
Multiband Multislice GE-EPI at 7 Tesla, With 16-Fold Acceleration Using Partial Parallel Imaging With Application to High Spatial and Temporal Whole-Brain FMRI
Steen Moeller,Essa Yacoub,Cheryl A. Olman,Edward J. Auerbach,John P. Strupp,Noam Harel,Kâmil Uğurbil +6 more
TL;DR: Parallel imaging in the form of multiband radiofrequency excitation, together with reduced k‐space coverage in the phase‐encode direction, was applied to human gradient echo functional MRI at 7 T for increased volumetric coverage and concurrent high spatial and temporal resolution.
Journal ArticleDOI
Multiplexed echo planar imaging for sub-second whole brain fmri and fast diffusion imaging
David A. Feinberg,David A. Feinberg,Steen Moeller,Stephen M. Smith,Edward J. Auerbach,Sudhir Ramanna,Matthew F. Glasser,Karla L. Miller,Kamil Ugurbil,Essa Yacoub +9 more
TL;DR: The novel M-EPI pulse sequence resulted in a significantly increased temporal resolution for whole brain fMRI, and as such, this new methodology can be used for studying non-stationarity in networks and generally for expanding and enriching the functional information.
Journal ArticleDOI
Blipped-controlled aliasing in parallel imaging for simultaneous multislice echo planar imaging with reduced g-factor penalty.
Kawin Setsompop,Borjan Gagoski,Jonathan R. Polimeni,Thomas Witzel,Thomas Witzel,Van J. Wedeen,Van J. Wedeen,Lawrence L. Wald,Lawrence L. Wald +8 more
TL;DR: In this paper, the authors introduce a method to create interslice image shifts in the phase encoding direction to increase the distance between aliasing pixels, induced using sign-and amplitude-modulated slice-select gradient blips simultaneous with the EPI phase encoding blips.
Journal ArticleDOI
A flow velocity zeugmatographic interlace for NMR imaging in humans
Paul R. Moran,Paul R. Moran +1 more
TL;DR: A flow sensitizing zeugmatographic phase-modulation interlace for NMR-imaging which is exactly analogous to Lauterbur's spatial-location-sensitizing magnetic field gradients and enables up to 6-D imaging of the joint density of spins delta (r,v).
Journal ArticleDOI
Use of multicoil arrays for separation of signal from multiple slices simultaneously excited.
David J. Larkman,Joseph V. Hajnal,Amy H. Herlihy,Glyn A. Coutts,Ian R. Young,Gosta J. Ehnholm +5 more
TL;DR: Increased acquisition efficiency has been achieved by exciting several slices simultaneously using the spatial encoding information inherent in a multicoil receiver system and a matrix inversion provides a solution to unfold these images.