Journal ArticleDOI
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks.
Vibeke Devold Valderhaug,Kristine Heiney,Ola Huse Ramstad,Geir Bråthen,Wei-Li Kuan,Stefano Nichele,Axel Sandvig,Ioanna Sandvig +7 more
TLDR
A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases, such as Parkinson's disease as discussed by the authors, where misfolded forms of α-synuclein proteins accumulate in hallmar...Abstract:
A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of α-synuclein proteins accumulate in hallmar...read more
Citations
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Self-Organised Critical Dynamics as a Key to Fundamental Features of Complexity in Physical, Biological, and Social Networks
Bosiljka Tadić,Roderick Melnik +1 more
TL;DR: In this paper, the authors study the field-driven spin dynamics on the hysteresis loop in a network with higher-order structures described by simplicial complexes, and demonstrate how the self-organised criticality occurs at the interplay of the complex topology and driving mode.
Journal ArticleDOI
Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson’s disease
TL;DR: A ‘synapse to network prodrome cascade’ wherein before overt cell death, pathological α-synuclein induces synaptic loss and contributes to aberrant network activity, which then gives rise to prodromal symptomology is proposed.
Journal ArticleDOI
Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro
TL;DR: In this article , the preformed fibril (PFF) PD model is applied with co-administered groups of butyrate and lipopolysaccharide to model the effects of the local gut microbiome.
Journal ArticleDOI
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
TL;DR: In this paper , a methodological approach for dissection and long-term culturing of adult lateral entorhinal layer II-neurons from AD-model mice was presented.
Posted ContentDOI
Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
TL;DR: In this paper , a methodological approach for microdissection and long-term culturing of adult lateral entorhinal layer II-neurons from AD-model mice was demonstrated.
References
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Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Power-Law Distributions in Empirical Data
TL;DR: This work proposes a principled statistical framework for discerning and quantifying power-law behavior in empirical data by combining maximum-likelihood fitting methods with goodness-of-fit tests based on the Kolmogorov-Smirnov (KS) statistic and likelihood ratios.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
Self-organized criticality
TL;DR: In this article, the authors show that certain extended dissipative dynamical systems naturally evolve into a critical state, with no characteristic time or length scales, and the temporal fingerprint of the self-organized critical state is the presence of flicker noise or 1/f noise; its spatial signature is the emergence of scale-invariant (fractal) structure.
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