Journal ArticleDOI
Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1
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TLDR
Evidence is provided that alteration of cellular redox states by treating cells with H2O2 or dithiothreitol impairs hypoxia signaling mechanisms and the expression of HIF-1 alpha protein in hypoxic cells.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1995-07-17. It has received 172 citations till now. The article focuses on the topics: Dithiothreitol & Transcription factor.read more
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Journal ArticleDOI
Regulation of mammalian o2 homeostasis by hypoxia-inducible factor 1
TL;DR: HIF-1 appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology.
Journal ArticleDOI
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Navdeep S. Chandel,Emin Maltepe,Eugene Goldwasser,Carol Mathieu,M. C. Simon,Paul T. Schumacker +5 more
TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).
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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Navdeep S. Chandel,David S. McClintock,C E Feliciano,T M Wood,J A Melendez,A M Rodriguez,Paul T. Schumacker +6 more
TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.
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Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions ITS STABILIZATION BY HYPOXIA DEPENDS ON REDOX-INDUCED CHANGES
Susana Salceda,Jaime Caro +1 more
TL;DR: Findings strongly suggest that the hypoxia induced changes in HIF-1alpha stability and subsequent gene activation are mediated by redox-induced changes.
Journal ArticleDOI
Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
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