Effect of amiodarone on mortality after myocardial infarction: A double-blind, placebo-controlled, pilot study
Leszek Ceremużyński,Elzbieta Kleczar,Maria Krzeminska-Pakula,Jerzy Kuch,Edmund Nartowicz,Jadwiga Smielak-Korombel,Andrzej Dyduszyński,Jerzy Maciejewicz,Teresa Zaleska,Elzbieta Lazarczyk-Kedzia,Janina Motyka,Barbara Paczkowska,Olga Sczaniecka,Salim Yusuf +13 more
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TLDR
This trial demonstrated a significant reduction in cardiac mortality and ventricular arrhythmias with amiodarone treatment, however, given the wide confidence intervals and borderline statistical significance of the trial, larger trials are needed to confirm or refute this view.About:
This article is published in Journal of the American College of Cardiology.The article was published on 1992-11-01 and is currently open access. It has received 283 citations till now. The article focuses on the topics: Amiodarone & Sudden death.read more
Citations
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1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction)
Thomas J. Ryan,Elliott M. Antman,Neil H. Brooks,Robert M. Califf,L. David Hillis,Loren F. Hiratzka,Elliot Rapaport,Barbara Riegel,R. O. Russell,Earl E. Smith,W. Douglas Weaver,Raymond J. Gibbons,Joseph S. Alpert,Kim A. Eagle,Timothy J. Gardner,Arthur Garson,Gabriel Gregoratos,Sidney C. Smith +17 more
TL;DR: These guidelines are intended for physicians, nurses, and allied healthcare personnel who care for patients with suspected or established acute myocardial infarction and promote rapid identification and treatment of patients with acute MI.
Journal ArticleDOI
ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines).
Gabriel Gregoratos,Jonathan Abrams,Andrew E. Epstein,Roger A. Freedman,David L. Hayes,Mark A. Hlatky,Richard E. Kerber,Gerald V. Naccarelli,Mark H. Schoenfeld,Michael J. Silka,Stephen L. Winters,Raymond J. Gibbons,Elliott M. Antman,Joseph S. Alpert,Loren F. Hiratzka,David P. Faxon,Alice K. Jacobs,Valentin Fuster,Sidney C. Smith +18 more
TL;DR: The current update of the ACC/AHA/NASPE Guidelines for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices includes several significant changes in the recommendations and in the supporting narrative portion.
Journal ArticleDOI
ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction
Thomas J. Ryan,Jeffrey L. Anderson,Elliott M. Antman,Blaine A. Braniff,Neil H. Brooks,Robert M. Califf,L. David Hillis,Loren F. Hiratzka,Elliott Rapaport,Barbara Riegel,R. O. Russell,Earl E. Smith,W. Douglas Weaver,James L. Ritchie,Melvin D. Cheitlin,Kim A. Eagle,Timothy J. Gardner,Arthur Garson,Raymond J. Gibbons,Richard P. Lewis,Robert A. O'Rourke +20 more
TL;DR: The American College of Cardiology and the American Heart Association request that the following format be used when citing this document: Ryan TJ, Antman EM, Brooks NH, Califf RM, Hillis LD, Hiratzka LF, Rapaport E, Riegel B, Russell RO, Smith EE III, Weaver WD.
Journal ArticleDOI
Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
Albert L. Waldo,A. John Camm,Hans deRuyter,Peter L. Friedman,Daniel J. MacNeil,John F Pauls,Bertram Pitt,Craig M. Pratt,Peter J. Schwartz,Enrico P Veltri +9 more
TL;DR: The prophylactic use of a specific potassium-channel blocker does not reduce mortality, and may be associated with increased mortality in high-risk patients after myocardial infarction.
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Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure.
Steven N. Singh,Ross D. Fletcher,Susan G. Fisher,Bramah N. Singh,H D Lewis,Prakash Deedwania,Barry M. Massie,Cindy Colling,D Lazzeri +8 more
TL;DR: Although amiodarone was effective in suppressing ventricular arrhythmias and improving ventricular function, it did not reduce the incidence of sudden death or prolong survival among patients with heart failure, except for a trend toward reduced mortality among those with nonischemic cardiomyopathy.
References
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal ArticleDOI
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
TL;DR: The addition of enalapril to conventional therapy significantly reduced mortality and hospitalizations for heart failure in patients with chronic congestive heart failure and reduced ejection fractions.
Journal ArticleDOI
Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. results of the survival and ventricular enlargement trial
Marc A. Pfeffer,Eugene Braunwald,Lemuel A. Moyé,Lofty L. Basta,Edward J. Brown,Thomas E. Cuddy,Barry R. Davis,Edward M. Geltman,Steven Goldman,Greg C. Flaker,Marc Klein,Gervasio A. Lamas,Milton Packer,Jacques R. Rouleau,Jean L. Rouleau,John D. Rutherford,John H. Wertheimer,C. Morton Hawkins +17 more
TL;DR: In patients with asymptomatic left ventricular dysfunction after myocardial infarction, long-term administration of captopril was associated with an improvement in survival and reduced morbidity and mortality due to major cardiovascular events.
Journal ArticleDOI
Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions.
TL;DR: The angiotensin-converting--enzyme inhibitor enalapril significantly reduced the incidence of heart failure and the rate of related hospitalizations, as compared with the rates in the group given placebo, among patients with asymptomatic left ventricular dysfunction.
Journal Article
Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction
William J. Rogers,Andrew E. Epstein,J. G. Arciniegas,Sharon M. Dailey,G. N. Kay,R. E. Little,W. A H MacLean,S. E. Papapietro,V. J. Plumb,S. Silber,A. R. Baker,M. Cox,C. Thomas,D. Von-Hagel,A. E. Walton,Craig M. Pratt,John J. Mahmarian,T. Eaton,G. Morris +18 more
TL;DR: It is concluded that neither encainide nor flecainide should be used in the treatment of patients with asymptomatic or minimally symptomatic ventricular arrhythmia after myocardial infarction, even though these drugs may be effective initially in suppressing ventricular arrhythmia.