Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity
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TLDR
In non-celiac gluten sensitivity patients anti-gliadin antibodies IgG persistence after gluten withdrawal was significantly correlated with the low compliance to gluten-free diet and a mild clinical response.Abstract:
Background
Non-celiac gluten sensitivity is a syndrome characterized by gastrointestinal and extra-intestinal symptoms occurring in a few hours/days after gluten and/or other wheat protein ingestion and rapidly improving after exclusion of potential dietary triggers. There are no established laboratory markers for non-celiac gluten sensitivity, although a high prevalence of first generation anti-gliadin antibodies of IgG class has been reported in this condition. This study was designed to characterize the effect of the gluten-free diet on anti-gliadin antibodies of IgG class in patients with non-celiac gluten sensitivity.read more
Citations
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Journal ArticleDOI
Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria
Carlo Catassi,Luca Elli,Bruno Bonaz,Gerd Bouma,Antonio Carroccio,Gemma Castillejo,Christophe Cellier,Fernanda Cristofori,Laura de Magistris,Jernej Dolinsek,Walburga Dieterich,Ruggiero Francavilla,Marios Hadjivassiliou,Wolfgang Holtmeier,Ute Körner,Daniel A. Leffler,Knut E.A. Lundin,Giuseppe Mazzarella,Chris J. J. Mulder,Nicoletta Pellegrini,Kamran Rostami,David S Sanders,Gry Irene Skodje,Detlef Schuppan,Reiner Ullrich,Umberto Volta,Marianne Williams,Victor F. Zevallos,Yurdagül Zopf,Alessio Fasano +29 more
TL;DR: Experts’ recommendations on how the diagnostic protocol should be performed for the confirmation of non-Celiac Gluten Sensitivity are reported, to help the clinician to reach a firm and positive diagnosis of NCGS.
Journal ArticleDOI
An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity
Umberto Volta,Maria Teresa Bardella,Antonino Salvatore Calabrò,Riccardo Troncone,Gino Roberto Corazza +4 more
TL;DR: This prospective survey shows that non-celiac gluten sensitivity has a strong correlation with female gender and adult age, and the prevalence of NCGS seems to be only slightly higher than that of celiac disease.
Journal ArticleDOI
Nonceliac Gluten Sensitivity
TL;DR: A better understanding of the clinical presentation of nonceliac gluten sensitivity is required, as well as its pathogenesis, epidemiology, management, and role in conditions such as irritable bowel syndrome, chronic fatigue, and autoimmunity.
Journal ArticleDOI
Celiac disease and non-celiac gluten sensitivity
TL;DR: Although a gluten-free diet is effective in most patients, this diet can be burdensome and can limit quality of life; consequently, non-dietary therapies are at various stages of development.
Journal ArticleDOI
Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease
Melanie Uhde,Mary Ajamian,Giacomo Caio,Roberto De Giorgio,Alyssa Indart,Peter H.R. Green,Elizabeth C. Verna,Umberto Volta,Armin Alaedini +8 more
TL;DR: Findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease.
References
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TL;DR: In a placebo-controlled, cross-over rechallenge study, there is no evidence of specific or dose-dependent effects of gluten in patients with NCGS placed diets low in FODMAPs.
Journal ArticleDOI
Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial
Jessica R Biesiekierski,Evan Newnham,Peter M. Irving,Jacqueline Susanne Barrett,Melissa Haines,James D. Doecke,Susan Joy Shepherd,Jane G. Muir,Peter R. Gibson +8 more
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