Journal ArticleDOI
Effect of intra-testicular melatonin injection on testicular functions, local and general immunity of a tropical rodent Funambulus pennanti
Raise Ahmad,Chandana Haldar +1 more
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TLDR
An increase in testicular as well as general immunity was observed in a duration-dependent manner following intra-testicular injection ofMelatonin decreased steroidogenesis by enhancing the primary effect of melatonin on Leydig cell endocrine function.Abstract:
Local antigonadotrophic action of melatonin in testes has never been correlated with local and general immune status of any rodent Intra-testicular injection of melatonin (25 μg/50 μl) for 10 days (MI-10D) and 20 days (MI-20D) was given to young adult male of Funambulus pennanti and testicular androgen receptor (AR), androgen binding protein (ABP) expression, 3β-hydroxysteroid dehydrogenase (3β-HSD) activity, and Mel1aR expression in thymus was checked along with general immune parameters Further, immunohistochemical localization of Mel1aR in testes was done Decreased AR, ABP expression, testes weight, 3β-HSD activity, testosterone level, and spermatogenesis but increased Mel1aR expression in thymus, immunoreactivity in testes, and testicular macrophages following injection was noted Lymphatic tissue weight, leukocyte, lymphocyte count, lymphocyte proliferation in spleen, thymus, plasma melatonin, and IL-2 level increased in a duration-dependent manner following intra-testicular injection Intra-testicular injection of melatonin decreased steroidogenesis by enhancing the primary effect of melatonin on Leydig cell endocrine function Along with reduced circulatory testosterone production, an increase in testicular as well as general immunity was observed in a duration-dependent manner Therefore, a local participation of melatonin in testes of F pennanti to control testicular androgen production is suggestedread more
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Journal ArticleDOI
Effects of Melatonin on Peripheral Reproductive Function: Regulation of Testicular GnIH and Testosterone
TL;DR: It is shown that the inhibition of sex steroid secretion can be seasonally mediated at the level of the gonad, by a mechanism involving melatonin and the gonadal GnIH system.
Journal ArticleDOI
The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent
TL;DR: It is shown that physiologically-relevant concentrations of corticosterone and metabolic stress (via use of the glucose utilization inhibitor 2-deoxy-D-glucose and the fatty acid oxidation inhibitor ethyl 2-mercaptoacetate) can directly decrease testosterone and estradiol secretion from luteinizing hormone and follicle-stimulating hormone-stimulated testes and ovaries.
Journal ArticleDOI
Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review
TL;DR: The literature data indicate that melatonin has important effects on steroidogenesis and male reproduction, and the melatonin-induced regulation of steroid hormones may differ among species.
Journal ArticleDOI
Melatonin Protects the Heart, Lungs and Kidneys from Oxidative Stress under Intermittent Hypobaric Hypoxia in Rats
TL;DR: Results indicated that melatonin decreased lipid peroxidation in heart, kidneys and lung under intermittent hypobaric hypoxia conditions, however, it did not exhibit any protective effect in liver, testis, epididymis and sperm count.
Journal ArticleDOI
Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells.
Shou-Long Deng,Zhi-Peng Wang,Cheng Jin,Xiao-Long Kang,Aalia Batool,Yan Zhang,Xiao-Yu Li,Xiu-Xia Wang,Su-Ren Chen,Chawnshang Chang,C. Yan Cheng,Zhengxing Lian,Yi-Xun Liu +12 more
TL;DR: It is found that 10-7 M melatonin increased testosterone production in co-cultured Leydig and Sertoli cells isolated from sheep, and this work suggests that melatonin may function through modulating melatonin receptor 1-regulated insulin-like growth factor-1 expression, as well as melatonin receptors 1-induced suppression of estrogen synthesis to increase androgen production in Co-culturing Leydigs and SERToli cells.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
TL;DR: The pineal gland can be rapidly removed from rodents with minimal damage to adjacent neural structures using a specially designed trephine, and since the mid 1960s, research on the gland has become a very active area of investigation.
Book
Steroid-Protein Interactions
TL;DR: The species specificity which had been observed in rat and human transcortin for the species specific corticosteroid has not been found to be a general phenomenon.
Journal ArticleDOI
Radioimmunoassay of serum concentrations of melatonin in sheep exposed to different lighting regimens.
M. D. Rollag,Gordon D. Niswender +1 more
TL;DR: A precipitous drop in serum concentrations of melatonin resulted when ewes experiencing peak melatonin concentrations were exposed to light and returned to peak levels when the lights were turned off 3.5 h later.
Journal ArticleDOI
Seasonal changes in immune function.
Randy J. Nelson,Gregory E. Demas +1 more
TL;DR: It is proposed that compromised immune function may be observed in some populations during particularly harsh winters when stressors override the enhancement of immune function evoked by short day lenghts.
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