Journal ArticleDOI
Effects of Acetylsalicylic Acid Ingestion on Maternal and Neonatal Hemostasis
TLDR
It is concluded that aspirin should be avoided during pregnancy because of the effects of maternal ingestion of acetylsalicylic acid (aspirin) within 10 days of delivery on maternal and neonatal hemostasis.Abstract:
In a case-control study, we evaluated the effects of maternal ingestion of acetylsalicylic acid (aspirin) within 10 days of delivery on maternal and neonatal hemostasis. Only one of 34 control maternal-neonatal pairs (3 per cent) had hemostatic abnormalities. In 10 pairs, when maternal aspirin ingestion occurred within five days of delivery, 6 of 10 mothers and 9 of the 10 infants had bleeding tendencies. Seven maternal-neonatal pairs in which aspirin was ingested 6 to 10 days before delivery were free of clinical bleeding. Among seven other mothers who ingested aspirin in the immediate post-partum period four of the seven (57 per cent) also had impaired hemostasis. Neonatal hemostatic abnormalities included numerous petechiae over the presenting part, hematuria, a cephalhematoma, subconjunctival hemorrhage, and bleeding from a circumcision. Maternal bleeding was confined to excessive intrapartum or post-partum blood loss. We conclude that aspirin should be avoided during pregnancy. If ingestion has occurred within five days of delivery, the neonate should be evaluated for the presence of bleeding.read more
Citations
More filters
Journal ArticleDOI
Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae.
TL;DR: Low-dose aspirin may restore prostacyclin/thromboxane imbalance, previously suggested as an important aetiological factor in PIH and pre-eclampsia, and be reinstated in mothers or infants.
Journal ArticleDOI
VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Shannon M. Bates,Ian A. Greer,Saskia Middeldorp,David L. Veenstra,Anne-Marie Prabulos,Per Olav Vandvik +5 more
TL;DR: In this article, the authors focused on the management of VTE and thrombophilia as well as the use of antithrombotic agents during pregnancy. But they did not consider the risk of pregnancy complications.
Journal ArticleDOI
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations
Gert Van Assche,Axel Dignass,Walter Reinisch,C. Janneke van der Woude,Andreas Sturm,Martine De Vos,Mario Guslandi,Bas Oldenburg,Iris Dotan,Philippe Marteau,Alessandro Ardizzone,Daniel C. Baumgart,Geert R. D'Haens,Paolo Gionchetti,Francisco Portela,Boris Vucelić,Johan D. Söderholm,Johanna C. Escher,Sibylle Koletzko,Kaija-Leena Kolho,Milan Lukas,Christian Mottet,Herbert Tilg,Severine Vermeire,F. Carbonnel,Andrew T. Cole,Gottfried Novacek,Max Reinshagen,Epameinondas V. Tsianos,Klaus Herrlinger,Yoram Bouhnik,Ralf Kiesslich,Eduard F. Stange,Simon Travis,James O. Lindsay +34 more
TL;DR: The aim of this Consensus was therefore critically to evaluate the optimal strategies for the management of post-operative recurrence in CD.
Journal ArticleDOI
Anti-inflammatory and immunosuppressive drugs and reproduction.
Monika Østensen,Munther A. Khamashta,Michael D. Lockshin,Ann L. Parke,Antonio Brucato,Howard Carp,Andrea Doria,Raj Rai,Pier Luigi Meroni,Irene Cetin,Ronald H. W. M. Derksen,Ware Branch,Mario Motta,Caroline Gordon,Guillermo Ruiz-Irastorza,Arsenio Spinillo,Deborah I. Friedman,Rolando Cimaz,Andrew Czeizel,J.C. Piette,Ricard Cervera,Roger A. Levy,Maurizio Clementi,Sara De Carolis,Michelle Petri,Yehuda Shoenfeld,D Faden,Guido Valesini,Angela Tincani +28 more
TL;DR: Benefits of anti-inflammatory, immunosuppressive and biological drugs during pregnancy and lactation, effects of these drugs on male and female fertility and possible long-term effects on infants exposed to drugs antenatally are discussed.
Journal ArticleDOI
Prevention of pre-eclampsia by early antiplatelet therapy
TL;DR: Antiplatelet therapy given early in pregnancy to high-risk patients may protect against pre-eclampsia and fetal growth retardation.
References
More filters
Journal ArticleDOI
Aggregation of blood platelets by adenosine diphosphate and its reversal.
Journal ArticleDOI
Inhibition of platelet prostaglandin synthetase by oral aspirin.
TL;DR: Platelet cyclooxygenase is more sensitive to inactivation by aspirin than enzyme in sheep seminal vesicles, which suggests that oral aspirin also inactivated megakaryocyte cyclo oxygengenase.
Journal ArticleDOI
A simple nonradioisotope technic for the determination of platelet life-span.
TL;DR: A normal platelet survival curve was constructed with a mean half-life of 4.4 days (range of 2.9 to 5.9 days) and values agree with the standard 51-Cr survivals in three patients with chronic idiopathic thrombocytopenic purpura.
Journal ArticleDOI
Altered Platelet Function in Newborns
TL;DR: In vitro mixing experiments suggested that the impaired ADP platelet aggregation was due neither to the presence of plasma ADP inhibitors, a refractory state due to increased circulating levels of ADP, anticoagulants, nor to a selected population of platelets.
Journal ArticleDOI
The effects of antenatal drug administration on aggregation of platelets of newborn infants.
Donald G. Corby,Irving Schulman +1 more
TL;DR: In vitro testing demonstrated that platelets of newborn infants are much more susceptible to the effects of membrane-active drugs than are those of adults.