Journal ArticleDOI
Efficacy and Safety of Lactobacillus plantarum DSM 9843 (LP299V) in the Prevention of Antibiotic-Associated Gastrointestinal Symptoms in Children-Randomized, Double-Blind, Placebo-Controlled Study.
Agnieszka Olek,Marek Woynarowski,Irini Lazou Ahrén,Jarosław Kierkuś,Piotr Socha,Niklas Larsson,Gunilla Önning +6 more
TLDR
No beneficial effect of LP299V compared with placebo was observed for the incidence of loose/watery stools, mean number of loose-wateryStools, or the incidenceof abdominal symptoms, andLP299V had a satisfactory safety profile.About:
This article is published in The Journal of Pediatrics.The article was published on 2017-07-01. It has received 41 citations till now. The article focuses on the topics: Placebo & Placebo-controlled study.read more
Citations
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Journal ArticleDOI
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.
Jotham Suez,Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Max Horn,Yotam Cohen,Andreas E. Moor,David Zeevi,Tal Korem,Eran Kotler,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Meirav Pevsner-Fischer,Hagit Shapiro,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.
Journal ArticleDOI
The pros, cons, and many unknowns of probiotics
TL;DR: This Perspective highlights key advances, challenges and limitations in striving toward an unbiased interpretation of the large amount of data regarding over-the-counter probiotics, and proposes avenues to improve the quality of evidence, transparency, public awareness and regulation of their use.
Journal ArticleDOI
Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis
TL;DR: The results suggests that probiotic use may be beneficial in the prevention of AAD among outpatients and the use of probiotics appears safe.
Journal ArticleDOI
Intestinal Barrier Function–Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota
TL;DR: The current knowledge of the role of the intestinal barrier in NAFLD is summarized and it is suggested that protecting the function of the intestine barrier is a new way to treatNAFLD and its related diseases.
References
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Journal ArticleDOI
Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
Colin Hill,Francisco Guarner,Gregor Reid,Glenn R. Gibson,Daniel Merenstein,Bruno Pot,Lorenzo Morelli,Roberto Berni Canani,Harry J. Flint,Seppo Salminen,Philip C. Calder,Mary Ellen Sanders +11 more
TL;DR: An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics and the appropriate use and scope of the term probiotic.
Journal ArticleDOI
Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression.
TL;DR: The hypothesis is that the ability of probiotic agents to inhibit adherence of attaching and effacing organisms to intestinal epithelial cells is mediated through their ability to increase expression of MUC2 and MUC3 intestinal mucins.
Journal ArticleDOI
Probiotics for the prevention of pediatric antibiotic‐associated diarrhea
Joshua Z. Goldenberg,Lyubov Lytvyn,Justin Steurich,Patricia C. Parkin,Sanjay Mahant,Bradley C. Johnston +5 more
TL;DR: The results from 22/23 trials reporting on the incidence of diarrhea show a precise benefit from probiotics compared to active, placebo or no treatment control, and this benefit remained statistically significant in an extreme plausible situation.
Journal ArticleDOI
Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice.
Michael Schultz,Claudia Veltkamp,L. A. Dieleman,Wetonia B. Grenther,Pricilla B. Wyrick,Susan L. Tonkonogy,R. Balfour Sartor +6 more
TL;DR: Results demonstrate that L. plantarum can attenuate immune-mediated colitis and suggest a potential therapeutic role for this agent in clinical inflammatory bowel diseases.
Journal ArticleDOI
A mannose-specific adherence mechanism in Lactobacillus plantarum conferring binding to the human colonic cell line HT-29.
TL;DR: A mannose-specificAdhesin has been identified in L. plantarum; this adhesin could be involved in the ability to colonize the intestine.