Journal ArticleDOI
Endolysins as emerging alternative therapeutic agents to counter drug-resistant infections.
TLDR
This review primarily reviews the recent advancements made in the evaluation of therapeutic potential of endolysins, including their origin, host range, applications and synergy with conventional and non conventional antimicrobial agents.About:
This article is published in International Journal of Antimicrobial Agents.The article was published on 2020-02-01. It has received 71 citations till now. The article focuses on the topics: Lysin.read more
Citations
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Journal ArticleDOI
Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases.
Olga Pacios,Lucia Blasco,Ines Bleriot,Laura Fernandez-Garcia,Mónica González Bardanca,Antón Ambroa,María M. López,Germán Bou,María Tomás +8 more
TL;DR: New anti-infectious strategies against multidrug-resistant (MDR) and persistent bacteria, as well as the rescue of Food and Drug Administration (FDA)-approved compounds (drug repurposing), are being explored.
Journal ArticleDOI
Phage-Encoded Endolysins.
Fatma Abdelrahman,Maheswaran Easwaran,Oluwasegun I. Daramola,Samar Ragab,Stephanie A. Lynch,Tolulope J. Oduselu,Fazal Mehmood Khan,Akomolafe Ayobami,Fazal Adnan,Eduard Torrents,Swapnil Sanmukh,Ayman El-Shibiny +11 more
TL;DR: In this paper, the synergy between endolysins and antibiotics is discussed, as well as the formulation of endolysin formulations for clinical trials involving endolySins, and the authors provide new insights into the synergy and synergy between the two drugs.
Journal ArticleDOI
A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes
Fazal Mehmood Khan,Vijay Singh Gondil,Changchang Li,Mengwei Jiang,Junhua Li,Junping Yu,Hongping Wei,Hang Yang +7 more
TL;DR: In this paper, an A. baumannii bacteriophage p54 was isolated and characterized, and a novel endolysin, namely LysAB54, showing low similarity with other well-known related endolysins, was cloned, expressed, and characterized from the bacteria p54.
Journal ArticleDOI
Synergistic effects of endolysin Lysqdvp001 and ε-poly-lysine in controlling Vibrio parahaemolyticus and its biofilms.
TL;DR: In this article, the synergistic antibacterial effects between endolysin Lysqdvp001 and e-poly-lysine (e-PL) against Vibrio parahaemolyticus (V. parahaemicus) were investigated.
Journal ArticleDOI
Synergistic action of phage phiIPLA-RODI and lytic protein CHAPSH3b: a combination strategy to target Staphylococcus aureus biofilms.
Ana Catarina Duarte,Ana Catarina Duarte,Lucía Fernández,Lucía Fernández,Vincent De Maesschalck,Vincent De Maesschalck,Diana Gutiérrez,Ana B. Campelo,Yves Briers,Rob Lavigne,Ana Rodríguez,Ana Rodríguez,Pilar García,Pilar García +13 more
TL;DR: In this paper, the combination of a phage-derived lytic protein, CHAPSH3b, and the virulent bacteriophage phiIPLA-RODI was investigated for the treatment of Staphylococcus aureus biofilms.
References
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Journal ArticleDOI
Holins: the protein clocks of bacteriophage infections.
TL;DR: Two proteins, an endolysin and a holin, are essential for host lysis by bacteriophage, and constitute one of the most diverse functional groups, with >100 known or putative holin sequences, which form >30 ortholog groups.
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Bacteriophage lysis: mechanism and regulation.
TL;DR: The available evidence suggests that holins oligomerize to form nonspecific holes and that this hole-forming step is the regulated step in phage lysis, which is as much an essential feature of holin function as is the hole formation itself.
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Resistance to antibiotics mediated by target alterations
TL;DR: The ideal antibiotic would be produced by rational design, rather than by the modification of a natural product, because inactivating enzymes commonly provide resistance to antibiotics that, like penicillin, are derived from natural products, although such enzymes have not been found for synthetic antibiotics.
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A bacteriolytic agent that detects and kills Bacillus anthracis.
TL;DR: PlyG is shown that the PlyG lysin, isolated from the γ phage of B. anthracis, specifically kills B.Anthracis isolates and other members of the B. Anthracis ‘cluster’ of bacilli in vitro and in vivo.
Journal ArticleDOI
Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme
TL;DR: It is shown that lysin represents a unique murein hydrolase that has a rapid lethal effect both in vitro and in vivo on group A streptococci, without affecting other indigenous microorganisms analyzed.