Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla.
Le Ba Vinh,Le Ba Vinh,Nguyen Thi Minh Nguyet,Liu Ye,Gao Dan,Nguyen Viet Phong,Hoang Le Tuan Anh,Young Ho Kim,Jong Seong Kang,Seo Young Yang,Inkyu Hwang +10 more
TLDR
Results imply that saponins from S. hexaphylla leaves have a definite advantage in the development of oral medications for the control of inflammatory responses.Abstract:
Stauntonia hexaphylla (Lardizabalaceae) has been used as a traditional herbal medicine in Korea and China for its anti-inflammatory and analgesic properties. As part of a bioprospecting program aimed at the discovery of new bioactive compounds from Korean medicinal plants, a phytochemical study of S. hexaphylla leaves was carried out leading to isolation of two oleanane-type triterpene saponins, 3-O-[β-d-glucopyranosyl (1→2)-α-l-arabinopyranosyl] oleanolic acid-28-O-[β-d-glucopyranosyl (1→6)-β-d-glucopyranosyl] ester (1) and 3-O-α-l-arabinopyranosyl oleanolic acid-28-O-[β-d-glucopyranosyl (1→6)-β-d-glucopyranosyl] ester (2). Their structures were established unambiguously by spectroscopic methods such as one- and two-dimensional nuclear magnetic resonance and infrared spectroscopies, high-resolution electrospray ionization mass spectrometry and chemical reactions. Their anti-inflammatory activities were examined for the first time with an animal model for the macrophage-mediated inflammatory response as well as a cell-based assay using an established macrophage cell line (RAW 264.7) in vitro. Together, it was concluded that the saponin constituents, when they were orally administered, exerted much more potent activities in vivo than their sapogenin core even though both the saponins and the sapogenin molecule inhibited the RAW 264.7 cell activation comparably well in vitro. These results imply that saponins from S. hexaphylla leaves have a definite advantage in the development of oral medications for the control of inflammatory responses.read more
Citations
More filters
Journal ArticleDOI
Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021
R. Miranda,Bárbara da Silva Mascarenhas de Jesus,Sandra Regina da Silva Luiz,C. B. Viana,Camila Rodrigues Adão Malafaia,Fabiana de Souza Figueiredo,Tatiane S. C. Carvalho,Matheus L. Silva,Vinicius S. Londero,T. A. da Costa-Silva,João Henrique G. Lago,Roberto Carlos Campos Martins +11 more
TL;DR: The anti-inflammatory effect and action as immunomodulators of triterpenes have been demonstrated in different studies as mentioned in this paper , which suggests that triterbenes could be appointed as natural products with future pharmaceutical applicability.
Journal ArticleDOI
Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases.
Xiaofen Li,Sili Liu,Liping Qu,Yang Chen,Chuqiao Yuan,Anquan Qin,Jiyi Liang,Qianqian Huang,Miao Jiang,Wenjun Zou +9 more
TL;DR: In this paper, the authors summarized the evidence of the effectiveness of dioscin and diosgenin in cardiac diseases, and provided a basis and reference for future research into their clinical applications and drug development in the field of cardiac disease.
Journal ArticleDOI
Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells.
Le Ba Vinh,Le Ba Vinh,Myungsook Heo,Nguyen Viet Phong,Irshad Ali,Young Sang Koh,Young Ho Kim,Seo Young Yang +7 more
TL;DR: Results suggest that phenolic and triterpenoid saponins from P. tenuifolia may be excellent anti-inflammatory agents.
Journal ArticleDOI
Four new phenolic compounds from the fruit of Cornus officinalis (Cornaceae) and their anti-inflammatory activity in RAW 264.7 cells.
Nguyen Thi Thu,Nguyen Thi Thuy An,Le Ba Vinh,Le Ba Vinh,Bui Thi Binh,Nguyen Thi Bich Thu,Nguyen Minh Khoi,Do Thi Ha +7 more
TL;DR: Using various chromatographic methods, four new phenolics, coroffesters A-D (1 − 4) were isolated from the fruit of Cornus officinalis (Cornaceae) as discussed by the authors.
Journal ArticleDOI
Network Pharmacology-Based Analysis on the Action Mechanism of Oleanolic Acid to Alleviate Osteoporosis.
TL;DR: Wang et al. as discussed by the authors investigated the underlying mechanism of antiosteoporosis (OP) action of Oleanolic acid by utilizing the network pharmacology approach and molecular docking methods.
References
More filters
Journal ArticleDOI
Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives.
TL;DR: The industrial uses and potential of saponins are discussed with respect to structure and activity, highlighting the undoubted value of these molecules as therapeutics.
Journal ArticleDOI
A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases.
Changho Lee,Jong-Hoon Kim +1 more
TL;DR: Both in vitro and in vivo results indicate that ginseng has potentially positive effects on heart disease through its various properties including antioxidation, reduced platelet adhesion, vasomotor regulation, improving lipid profiles, and influencing various ion channels.
Journal ArticleDOI
Extraction and quantification of saponins: A review
TL;DR: A review of the saponin extraction with emphasis on conventional and green technology techniques employed in previous works by relating to their specific objective in each study to provide a point of reference to researchers who wish to design experiment to suit their particular objective in swift.
Journal ArticleDOI
Targeting Inflammation in Cancer Prevention and Therapy
TL;DR: Both NSAIDs and more potent anti-inflammatory antibody-based drugs need to be tested for their ability to augment the efficacy of more conventional therapeutic approaches on the basis of tumor resection, radiation, and cytotoxic chemicals.
Journal ArticleDOI
Antifungal activity of C-27 steroidal saponins
TL;DR: The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains, suggesting that the C-27 steroidal Saponins may be considered potential antIFungal leads for further preclinical study.